Increased NGF-like activity in young but not aged rat hippocampus after septal lesions

Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay...

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Veröffentlicht in:	Neurobiology of aging 1994-05, Vol.15 (3), p.337-346
Hauptverfasser:	Scott, Samuel A., Liang, Shi, Weingartner, Jean A., Crutcher, Keith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Animals Bioassay Biological and medical sciences Brain - growth & development Brain - physiology Denervation Development. Senescence. Regeneration. Transplantation ELISA Enzyme-Linked Immunosorbent Assay F344 Female Fundamental and applied biological sciences. Psychology Ganglia, Sympathetic - cytology Ganglia, Sympathetic - physiology Hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Humans Nerve Growth Factors - metabolism Neurite Plasticity Neurites - physiology NGF Rat Rats Rats, Inbred F344 Recombinant Proteins - pharmacology Septum Sprouting Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs
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