Increased NGF-like activity in young but not aged rat hippocampus after septal lesions
Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay...
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| Veröffentlicht in: | Neurobiology of aging 1994-05, Vol.15 (3), p.337-346 |
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| creator | Scott, Samuel A. Liang, Shi Weingartner, Jean A. Crutcher, Keith A. |
| description | Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay and an immunoassay were used to examine the effect of a medial septal lesion on hippocampal NGF levels in young adult (2–5 months) and aged (24 months) Fischer 344 rats. No significant differences were detected between normal young and aged rats, in agreement with earlier results. Following medial septal lesions, however, only young rats demonstrated significant increases in hippocampal NGF-like activity. These results support the hypothesis that the age-related deficit in sympathetic sprouting results from an attenuated neurotrophic response to hippocampal denervation. |
| doi_str_mv | 10.1016/0197-4580(94)90029-9 |
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This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay and an immunoassay were used to examine the effect of a medial septal lesion on hippocampal NGF levels in young adult (2–5 months) and aged (24 months) Fischer 344 rats. No significant differences were detected between normal young and aged rats, in agreement with earlier results. Following medial septal lesions, however, only young rats demonstrated significant increases in hippocampal NGF-like activity. These results support the hypothesis that the age-related deficit in sympathetic sprouting results from an attenuated neurotrophic response to hippocampal denervation.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(94)90029-9</identifier><identifier>PMID: 7936058</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aging ; Aging - metabolism ; Animals ; Bioassay ; Biological and medical sciences ; Brain - growth & development ; Brain - physiology ; Denervation ; Development. Senescence. Regeneration. Transplantation ; ELISA ; Enzyme-Linked Immunosorbent Assay ; F344 ; Female ; Fundamental and applied biological sciences. Psychology ; Ganglia, Sympathetic - cytology ; Ganglia, Sympathetic - physiology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - growth & development ; Hippocampus - metabolism ; Humans ; Nerve Growth Factors - metabolism ; Neurite Plasticity ; Neurites - physiology ; NGF ; Rat ; Rats ; Rats, Inbred F344 ; Recombinant Proteins - pharmacology ; Septum ; Sprouting ; Sympathetic Nervous System - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 1994-05, Vol.15 (3), p.337-346</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-70c398781756ab85455d6c5735615fbf35c1d8a7c613a7e5345b9d9025fc7c733</citedby><cites>FETCH-LOGICAL-c386t-70c398781756ab85455d6c5735615fbf35c1d8a7c613a7e5345b9d9025fc7c733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0197458094900299$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3359362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7936058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, Samuel A.</creatorcontrib><creatorcontrib>Liang, Shi</creatorcontrib><creatorcontrib>Weingartner, Jean A.</creatorcontrib><creatorcontrib>Crutcher, Keith A.</creatorcontrib><title>Increased NGF-like activity in young but not aged rat hippocampus after septal lesions</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay and an immunoassay were used to examine the effect of a medial septal lesion on hippocampal NGF levels in young adult (2–5 months) and aged (24 months) Fischer 344 rats. No significant differences were detected between normal young and aged rats, in agreement with earlier results. Following medial septal lesions, however, only young rats demonstrated significant increases in hippocampal NGF-like activity. These results support the hypothesis that the age-related deficit in sympathetic sprouting results from an attenuated neurotrophic response to hippocampal denervation.</description><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Bioassay</subject><subject>Biological and medical sciences</subject><subject>Brain - growth & development</subject><subject>Brain - physiology</subject><subject>Denervation</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>F344</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Sympathetic - cytology</subject><subject>Ganglia, Sympathetic - physiology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neurite Plasticity</subject><subject>Neurites - physiology</subject><subject>NGF</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Septum</subject><subject>Sprouting</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A4UcRPRQTTZN0lwEEb9A9KJeQzqdarTb1iQV9t_bdZc9eprDPO_LzEPIIWfnnHF1wbjRWS4LdmryM8PY1GRmg0y4lEXGc6M3yWSN7JDdGD8ZYzrXaptsayMUk8WEvD20ENBFrOjT3W3W-C-kDpL_8WlOfUvn3dC-03JItO0Sde8jF1yiH77vO3CzfojU1QkDjdgn19AGo-_auE-2atdEPFjNPfJ6e_NyfZ89Pt89XF89ZiAKlTLNQJhCF1xL5cpC5lJWCqQWUnFZl7WQwKvCaVBcOI1S5LI0lWFTWYMGLcQeOVn29qH7HjAmO_MRsGlci90QrVZ6_JPrEcyXIIQuxoC17YOfuTC3nNmFTrtwZReurMntn05rxtjRqn8oZ1itQyt_4_54tXcRXFMH14KPa0wIOYLTEbtcYji6-PEYbASPLWDlA0KyVef_v-MX9KiP-w</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Scott, Samuel A.</creator><creator>Liang, Shi</creator><creator>Weingartner, Jean A.</creator><creator>Crutcher, Keith A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Increased NGF-like activity in young but not aged rat hippocampus after septal lesions</title><author>Scott, Samuel A. ; Liang, Shi ; Weingartner, Jean A. ; Crutcher, Keith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-70c398781756ab85455d6c5735615fbf35c1d8a7c613a7e5345b9d9025fc7c733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Bioassay</topic><topic>Biological and medical sciences</topic><topic>Brain - growth & development</topic><topic>Brain - physiology</topic><topic>Denervation</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>F344</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Sympathetic - cytology</topic><topic>Ganglia, Sympathetic - physiology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Neurite Plasticity</topic><topic>Neurites - physiology</topic><topic>NGF</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Septum</topic><topic>Sprouting</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, Samuel A.</creatorcontrib><creatorcontrib>Liang, Shi</creatorcontrib><creatorcontrib>Weingartner, Jean A.</creatorcontrib><creatorcontrib>Crutcher, Keith A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, Samuel A.</au><au>Liang, Shi</au><au>Weingartner, Jean A.</au><au>Crutcher, Keith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased NGF-like activity in young but not aged rat hippocampus after septal lesions</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>15</volume><issue>3</issue><spage>337</spage><epage>346</epage><pages>337-346</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Sympathetic sprouting in the hippocampus following septal denervation is thought to involve nerve growth factor (NGF). This sprouting response is dramatically reduced in aged rats, but immunological assays reveal no age-related decline in hippocampal NGF levels. In the present study, both a bioassay and an immunoassay were used to examine the effect of a medial septal lesion on hippocampal NGF levels in young adult (2–5 months) and aged (24 months) Fischer 344 rats. No significant differences were detected between normal young and aged rats, in agreement with earlier results. Following medial septal lesions, however, only young rats demonstrated significant increases in hippocampal NGF-like activity. These results support the hypothesis that the age-related deficit in sympathetic sprouting results from an attenuated neurotrophic response to hippocampal denervation.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>7936058</pmid><doi>10.1016/0197-4580(94)90029-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Aging Aging - metabolism Animals Bioassay Biological and medical sciences Brain - growth & development Brain - physiology Denervation Development. Senescence. Regeneration. Transplantation ELISA Enzyme-Linked Immunosorbent Assay F344 Female Fundamental and applied biological sciences. Psychology Ganglia, Sympathetic - cytology Ganglia, Sympathetic - physiology Hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Humans Nerve Growth Factors - metabolism Neurite Plasticity Neurites - physiology NGF Rat Rats Rats, Inbred F344 Recombinant Proteins - pharmacology Septum Sprouting Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs |
| title | Increased NGF-like activity in young but not aged rat hippocampus after septal lesions |
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