A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells

HIV infection depletes the immune system of the coordinating functions of CD4+ T cells and APCs, whereas the population of CD8+ CTLs remains largely intact: functional but undirected. We have developed a humanized bispecific immunoadhesin-antibody (BIA) that redirects these remaining T cells to kill...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-11, Vol.153 (9), p.4268-4280
Hauptverfasser:	Chamow, SM, Zhang, DZ, Tan, XY, Mhatre, SM, Marsters, SA, Peers, DH, Byrn, RA, Ashkenazi, A, Junghans, RP
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibodies, Bispecific - immunology Antibody Affinity Blotting, Western CD3 Complex - immunology CD4 Immunoadhesins - immunology Cell Line Cytotoxicity, Immunologic - immunology Electrophoresis, Polyacrylamide Gel HIV-1 - immunology Humans Hybridomas - immunology T-Lymphocytes, Cytotoxic - immunology Transfection
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