Clostridial septicemia complicating the course of leukemia
The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of...
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| Veröffentlicht in: | Cancer 1986-05, Vol.57 (10), p.2045-2048 |
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| container_title | Cancer |
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| creator | Caya, James G. Farmer, Silas G. Ritch, Paul S. Wollenberg, Nancy J. Tieu, Thu M. Oechler, Herbert W. Spivey, Michael |
| description | The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectively. All patients for whom remission status was known were in leukemic relapse. Fever was a presenting complaint in at least 36 patients whereas neutropenia, thrombocytopenia, and gastrointestinal lesions were noted in 100%, 90.9%, and 87.9%, respectively, of the patients for whom information on these parameters was available. Overall mortality from clostridial septicemia was 78%; none of the children and none of the patients with intravascular hemolysis survived. Overall, antibiotic therapy resulted in a 40% survival rate. However, among patients receiving beta lactam and/or chloramphenicol therapy, 57% survived their episode of clostridial septicemia. Prompt initiation of appropriate antimicrobial therapy offers the best chance of survival in leukemia patients with clostridial septicemia. |
| doi_str_mv | 10.1002/1097-0142(19860515)57:10<2045::AID-CNCR2820571028>3.0.CO;2-O |
| format | Article |
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There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectively. All patients for whom remission status was known were in leukemic relapse. Fever was a presenting complaint in at least 36 patients whereas neutropenia, thrombocytopenia, and gastrointestinal lesions were noted in 100%, 90.9%, and 87.9%, respectively, of the patients for whom information on these parameters was available. Overall mortality from clostridial septicemia was 78%; none of the children and none of the patients with intravascular hemolysis survived. Overall, antibiotic therapy resulted in a 40% survival rate. However, among patients receiving beta lactam and/or chloramphenicol therapy, 57% survived their episode of clostridial septicemia. Prompt initiation of appropriate antimicrobial therapy offers the best chance of survival in leukemia patients with clostridial septicemia.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19860515)57:10<2045::AID-CNCR2820571028>3.0.CO;2-O</identifier><identifier>PMID: 3456820</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Child ; Clostridium Infections - complications ; Clostridium Infections - drug therapy ; Clostridium Infections - mortality ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemia - complications ; Leukemia, Lymphoid - complications ; Leukemia, Myeloid, Acute - complications ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Sepsis - drug therapy ; Sepsis - etiology ; Sepsis - mortality</subject><ispartof>Cancer, 1986-05, Vol.57 (10), p.2045-2048</ispartof><rights>Copyright © 1986 American Cancer Society</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5018-adcf8008215952370829368e4399d2b896304d9112a549c5cf24ab9d24b5afed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8661648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3456820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caya, James G.</creatorcontrib><creatorcontrib>Farmer, Silas G.</creatorcontrib><creatorcontrib>Ritch, Paul S.</creatorcontrib><creatorcontrib>Wollenberg, Nancy J.</creatorcontrib><creatorcontrib>Tieu, Thu M.</creatorcontrib><creatorcontrib>Oechler, Herbert W.</creatorcontrib><creatorcontrib>Spivey, Michael</creatorcontrib><title>Clostridial septicemia complicating the course of leukemia</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectively. All patients for whom remission status was known were in leukemic relapse. Fever was a presenting complaint in at least 36 patients whereas neutropenia, thrombocytopenia, and gastrointestinal lesions were noted in 100%, 90.9%, and 87.9%, respectively, of the patients for whom information on these parameters was available. Overall mortality from clostridial septicemia was 78%; none of the children and none of the patients with intravascular hemolysis survived. Overall, antibiotic therapy resulted in a 40% survival rate. However, among patients receiving beta lactam and/or chloramphenicol therapy, 57% survived their episode of clostridial septicemia. Prompt initiation of appropriate antimicrobial therapy offers the best chance of survival in leukemia patients with clostridial septicemia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Clostridium Infections - complications</subject><subject>Clostridium Infections - drug therapy</subject><subject>Clostridium Infections - mortality</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia - complications</subject><subject>Leukemia, Lymphoid - complications</subject><subject>Leukemia, Myeloid, Acute - complications</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - etiology</subject><subject>Sepsis - mortality</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF9LHDEUxYNU7Gr9CIV5KEUfZnvzd5JVBBlbK0gHSgUfCiGbyWjazM46maH47Zthtwv2odCnJPecezj5IXSFYY4ByAcMqsgBM3KClRTAMT_lxQLDOQHGF4vLm6u8_FJ-JZIALzAQeUHnMC-rM5JXe2i2W3-FZgAgc87o_Wt0GOOP9CwIpwfogDIu0v4MLcrQxaH3tTchi249eOtabzLbtevgrRn86iEbHl0ajH10WddkwY0_J88btN-YEN3x9jxCd58-fis_57fV9U15eZtbDljmpraNTD0I5ooTWqSbokI6RpWqyVIqQYHVCmNiOFOW24Yws0wSW3LTuJoeofeb3HXfPY0uDrr10boQzMp1Y9SFKNJnsEjG7xuj7bsYe9fode9b0z9rDHpCqyc2emKj_6DVvJjUCa3WCa1-iVZTDbqsNNFVin-77TEuW1fvwrcsk_5uq5toTWh6s7I-7mxSCCyYTLaHje2XD-75Pyv-s-FfCv0NA7eiBA</recordid><startdate>19860515</startdate><enddate>19860515</enddate><creator>Caya, James G.</creator><creator>Farmer, Silas G.</creator><creator>Ritch, Paul S.</creator><creator>Wollenberg, Nancy J.</creator><creator>Tieu, Thu M.</creator><creator>Oechler, Herbert W.</creator><creator>Spivey, Michael</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860515</creationdate><title>Clostridial septicemia complicating the course of leukemia</title><author>Caya, James G. ; Farmer, Silas G. ; Ritch, Paul S. ; Wollenberg, Nancy J. ; Tieu, Thu M. ; Oechler, Herbert W. ; Spivey, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-adcf8008215952370829368e4399d2b896304d9112a549c5cf24ab9d24b5afed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Clostridium Infections - complications</topic><topic>Clostridium Infections - drug therapy</topic><topic>Clostridium Infections - mortality</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia - complications</topic><topic>Leukemia, Lymphoid - complications</topic><topic>Leukemia, Myeloid, Acute - complications</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis - etiology</topic><topic>Sepsis - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caya, James G.</creatorcontrib><creatorcontrib>Farmer, Silas G.</creatorcontrib><creatorcontrib>Ritch, Paul S.</creatorcontrib><creatorcontrib>Wollenberg, Nancy J.</creatorcontrib><creatorcontrib>Tieu, Thu M.</creatorcontrib><creatorcontrib>Oechler, Herbert W.</creatorcontrib><creatorcontrib>Spivey, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caya, James G.</au><au>Farmer, Silas G.</au><au>Ritch, Paul S.</au><au>Wollenberg, Nancy J.</au><au>Tieu, Thu M.</au><au>Oechler, Herbert W.</au><au>Spivey, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clostridial septicemia complicating the course of leukemia</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1986-05-15</date><risdate>1986</risdate><volume>57</volume><issue>10</issue><spage>2045</spage><epage>2048</epage><pages>2045-2048</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>The authors report an analysis of 47 leukemia patients (including 9 from our own medical center) whose courses were complicated by 48 episodes of clostridial septicemia. There were 36 adults and 11 children; acute myelogenous leukemia and acute lymphoblastic leukemia accounted for 61.7% and 14.9% of cases, respectively. All patients for whom remission status was known were in leukemic relapse. Fever was a presenting complaint in at least 36 patients whereas neutropenia, thrombocytopenia, and gastrointestinal lesions were noted in 100%, 90.9%, and 87.9%, respectively, of the patients for whom information on these parameters was available. Overall mortality from clostridial septicemia was 78%; none of the children and none of the patients with intravascular hemolysis survived. Overall, antibiotic therapy resulted in a 40% survival rate. However, among patients receiving beta lactam and/or chloramphenicol therapy, 57% survived their episode of clostridial septicemia. Prompt initiation of appropriate antimicrobial therapy offers the best chance of survival in leukemia patients with clostridial septicemia.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3456820</pmid><doi>10.1002/1097-0142(19860515)57:10<2045::AID-CNCR2820571028>3.0.CO;2-O</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Anti-Bacterial Agents - therapeutic use Biological and medical sciences Child Clostridium Infections - complications Clostridium Infections - drug therapy Clostridium Infections - mortality Female Hematologic and hematopoietic diseases Humans Leukemia - complications Leukemia, Lymphoid - complications Leukemia, Myeloid, Acute - complications Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Sepsis - drug therapy Sepsis - etiology Sepsis - mortality |
| title | Clostridial septicemia complicating the course of leukemia |
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