Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]

Previously we have found that binding of the nonpeptide substance P antagonist, CP 96,345, to the neurokinin-1 (NK-1) receptor was critically dependent on two short segments adjacent to the top of transmembrane segments (TM) V and VI, called segments A (residues 183-195) and D (residues 271-276), re...

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Veröffentlicht in:	The Journal of biological chemistry 1994-09, Vol.269 (39), p.23959-23964
Hauptverfasser:	U Gether, L Nilsson, J A Lowe, 3rd, T W Schwartz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biphenyl Compounds - metabolism Cells, Cultured Hypnotics and Sedatives - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Sequence Data Mutation Receptors, Neurokinin-1 - chemistry Receptors, Neurokinin-1 - metabolism
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