Development of C5a receptor antagonists. Differential loss of functional responses

C5a is a 74-amino acid glycoprotein generated on activation of the C system. The responses evoked by C5a, both in vitro and in vivo, and its association with inflammatory diseases, suggest that a receptor antagonist would be of considerable therapeutic importance. However, efforts at generating anta...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-11, Vol.153 (9), p.4200-4205
Hauptverfasser:	Konteatis, ZD, Siciliano, SJ, Van Riper, G, Molineaux, CJ, Pandya, S, Fischer, P, Rosen, H, Mumford, RA, Springer, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Calcium - metabolism Cell Degranulation - physiology Chemotaxis, Leukocyte - physiology Complement C5a - agonists Complement C5a - antagonists & inhibitors Complement C5a - chemistry Complement C5a - metabolism Flow Cytometry GTP Phosphohydrolases - metabolism Humans Molecular Sequence Data Neutrophils - metabolism Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology Peroxidase - metabolism Protein Binding
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