Stromal expression of c-Ets1 transcription factor correlates with tumor invasion

The stroma reaction has an important role in tumor growth, invasion, and metastasis. In various invasive human carcinomas, as well as in a mouse model for tumor invasion, transcripts encoding the transcription factor c-Ets1 were detected within stromal fibroblasts, whereas they were absent in epithe...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-11, Vol.54 (21), p.5683-5688
Hauptverfasser:	WERNERT, N, GILLES, F, FAFEUR, V, BOUALI, F, RAES, M.-B, PYKE, C, DUPRESSOIR, T, SEITZ, G, VANDENBUNDER, B, STEHELIN, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biological and medical sciences Collagenases - analysis Collagenases - genetics Dissemination Female Fibroblast Growth Factor 2 - pharmacology Fibroblasts - chemistry Humans In Situ Hybridization Male Matrix Metalloproteinase 3 Medical sciences Metalloendopeptidases - analysis Metalloendopeptidases - genetics Mice Mice, SCID Middle Aged Neoplasm Invasiveness Neoplasms - chemistry Neoplasms - pathology Oncogene Proteins Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-ets RNA, Messenger - analysis Transcription Factors - analysis Transcription Factors - genetics Transcription, Genetic Transforming Growth Factor alpha Transforming Growth Factor beta - pharmacology Tumor cell Tumors Urokinase-Type Plasminogen Activator - analysis Urokinase-Type Plasminogen Activator - genetics
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