Modification of testicular cytochrome P-450 after fenitrothion administration
1. 1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level. 2. 2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochro...
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| Veröffentlicht in: | General pharmacology 1994-05, Vol.25 (3), p.499-503 |
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| container_title | General pharmacology |
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| creator | Clos, M.Victoria Ramoneda, Montserrat Garcia, Gloria |
| description | 1.
1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level.
2.
2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b
5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days).
3.
3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller.
4.
4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration. |
| doi_str_mv | 10.1016/0306-3623(94)90205-4 |
| format | Article |
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1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level.
2.
2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b
5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days).
3.
3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller.
4.
4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(94)90205-4</identifier><identifier>PMID: 7926597</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Androgens - metabolism ; Animals ; Biological and medical sciences ; Cytochrome P-450 Enzyme System - drug effects ; Fenitrothion - pharmacology ; Hydroxylation ; Male ; Medical sciences ; Microsomes - drug effects ; Microsomes - enzymology ; Pesticides, fertilizers and other agrochemicals toxicology ; Rats ; Rats, Sprague-Dawley ; Testis - drug effects ; Testis - enzymology ; Toxicology ; Xenobiotics - metabolism</subject><ispartof>General pharmacology, 1994-05, Vol.25 (3), p.499-503</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-7f7251ccefd8d317a1e3854c373e52fa8e7322480e928bbb72729633715ce7d63</citedby><cites>FETCH-LOGICAL-c386t-7f7251ccefd8d317a1e3854c373e52fa8e7322480e928bbb72729633715ce7d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4110764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7926597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clos, M.Victoria</creatorcontrib><creatorcontrib>Ramoneda, Montserrat</creatorcontrib><creatorcontrib>Garcia, Gloria</creatorcontrib><title>Modification of testicular cytochrome P-450 after fenitrothion administration</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level.
2.
2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b
5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days).
3.
3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller.
4.
4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration.</description><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 Enzyme System - drug effects</subject><subject>Fenitrothion - pharmacology</subject><subject>Hydroxylation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsomes - drug effects</subject><subject>Microsomes - enzymology</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Testis - drug effects</subject><subject>Testis - enzymology</subject><subject>Toxicology</subject><subject>Xenobiotics - metabolism</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS6ENFFNa8mzUYQ8QWKLnQdMukNRtpGk4ww_952Zpilq7s43zlcPoSOCb4kmIgrzLAomaDsXPELhSmuSr6DpqSWqsSYkF003SL76CClL4wxrSidoIlUVFRKTtHLS2i889ZkH_oiuCJDyt4uWhMLu8zBfsbQQfFW8goXxmWIhYPe5xjy59gwTed7n3JcDRyiPWfaBEebO0Mf93fvt4_l8-vD0-3Nc2lZLXIpnaQVsRZcUzeMSEOA1RW3TDKoqDM1SEYprzEoWs_nc0klVYIxSSoLshFshs7Wu98x_CyGj3Xnk4W2NT2ERdJSSK4GfgD5GrQxpBTB6e_oOxOXmmA9WtSjIj0q0orrlUXNh9rJZn8x76DZljbahvx0k5tkTeui6a1PW4wTgqUYZ67XGAwufj1EnayH3kLjI9ism-D__-MPAx6NPw</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Clos, M.Victoria</creator><creator>Ramoneda, Montserrat</creator><creator>Garcia, Gloria</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Modification of testicular cytochrome P-450 after fenitrothion administration</title><author>Clos, M.Victoria ; Ramoneda, Montserrat ; Garcia, Gloria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-7f7251ccefd8d317a1e3854c373e52fa8e7322480e928bbb72729633715ce7d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 Enzyme System - drug effects</topic><topic>Fenitrothion - pharmacology</topic><topic>Hydroxylation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsomes - drug effects</topic><topic>Microsomes - enzymology</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Testis - drug effects</topic><topic>Testis - enzymology</topic><topic>Toxicology</topic><topic>Xenobiotics - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Clos, M.Victoria</creatorcontrib><creatorcontrib>Ramoneda, Montserrat</creatorcontrib><creatorcontrib>Garcia, Gloria</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clos, M.Victoria</au><au>Ramoneda, Montserrat</au><au>Garcia, Gloria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of testicular cytochrome P-450 after fenitrothion administration</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>25</volume><issue>3</issue><spage>499</spage><epage>503</epage><pages>499-503</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level.
2.
2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b
5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days).
3.
3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller.
4.
4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7926597</pmid><doi>10.1016/0306-3623(94)90205-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | General pharmacology, 1994-05, Vol.25 (3), p.499-503 |
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| language | eng |
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| subjects | Androgens - metabolism Animals Biological and medical sciences Cytochrome P-450 Enzyme System - drug effects Fenitrothion - pharmacology Hydroxylation Male Medical sciences Microsomes - drug effects Microsomes - enzymology Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Sprague-Dawley Testis - drug effects Testis - enzymology Toxicology Xenobiotics - metabolism |
| title | Modification of testicular cytochrome P-450 after fenitrothion administration |
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