Characterization of a silencer regulatory element in the human interferon-gamma promoter

Previous analysis of the human interferon-gamma (IFN-gamma promoter indicated that the region of DNA from -251 to -215 (designated here as BE (binding element)) possessed silencer activity, as deletion of this region caused an increase in promoter activity. Based on this finding, we have conducted a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1994-10, Vol.269 (41), p.25728-25734
Hauptverfasser:	Ye, J, Ghosh, P, Cippitelli, M, Subleski, J, Hardy, K J, Ortaldo, J R, Young, H A
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites CD4-Positive T-Lymphocytes - cytology Cell Line DNA Mutational Analysis DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism Erythroid-Specific DNA-Binding Factors Gene Expression Regulation Genes, Reporter Humans Interferon-gamma - biosynthesis Interferon-gamma - genetics Macromolecular Substances Molecular Sequence Data Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics Protein Binding Transcription Factors - isolation & purification Transfection YY1 Transcription Factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!