Cytogenetic findings in nodular paragranuloma (Hodgkin's disease with lymphocytic predominance; nodular) and in progressively transformed germinal centers

Cytogenetic studies were performed in a case of progressively transformed germinal centers (PTGC), and in a case of nodular paragranuloma (NP; Hodgkin's disease with lymphocytic predominance, nodular type). No cytogenetic abnormalities were detected in PTGC. hromosomal aberrations (hyperdiploid...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1986-04, Vol.21 (4), p.319-325
Hauptverfasser:	Hansmann, Martin-Leo, Gödde-Salz, Elisabeth, Hui, Pak-Kwan, Müller-Hermelink, Hans-Konrad, Lennert, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chromosome Aberrations Chromosome Banding Female Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - pathology Humans Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymph Nodes - ultrastructure Lymphocytes - pathology Male Medical sciences Ploidies
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container_end_page	325
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container_title	Cancer genetics and cytogenetics
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creator	Hansmann, Martin-Leo Gödde-Salz, Elisabeth Hui, Pak-Kwan Müller-Hermelink, Hans-Konrad Lennert, Karl
description	Cytogenetic studies were performed in a case of progressively transformed germinal centers (PTGC), and in a case of nodular paragranuloma (NP; Hodgkin's disease with lymphocytic predominance, nodular type). No cytogenetic abnormalities were detected in PTGC. hromosomal aberrations (hyperdiploidy, 6q−, +21, and several unidentified markers) were found in NP. The results support the proposal that PTGC are reactive in nature and NP is a neoplasm. Chromosomal analysis could provide practical diagnostic aids in the differental diagnosis of PTGC and NP.
doi_str_mv	10.1016/0165-4608(86)90212-8
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source	MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects	Adult Biological and medical sciences Chromosome Aberrations Chromosome Banding Female Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - pathology Humans Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymph Nodes - ultrastructure Lymphocytes - pathology Male Medical sciences Ploidies
title	Cytogenetic findings in nodular paragranuloma (Hodgkin's disease with lymphocytic predominance; nodular) and in progressively transformed germinal centers
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