Ascorbic acid synthesis is stimulated by enhanced glycogenolysis in murine liver
Ascorbic acid synthesis was stimulated by glucagon, dibutyryl cyclic AMP, as well as phenylephrine, vasopressin or okadaic acid, in hepatocytes prepared from fed mice. However, no such effect was observed in glycogen-depleted cells from starved animals, either in the presence or absence of glucose....
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| Veröffentlicht in: | FEBS letters 1994-09, Vol.352 (1), p.4-6 |
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| creator | Braun, László Garzó, Tamás Mandl, József Bánhegyi, Gábor |
| description | Ascorbic acid synthesis was stimulated by glucagon, dibutyryl cyclic AMP, as well as phenylephrine, vasopressin or okadaic acid, in hepatocytes prepared from fed mice. However, no such effect was observed in glycogen-depleted cells from starved animals, either in the presence or absence of glucose. The rate of ascorbate synthesis showed close correlation with the glucose release by hepatocytes. In mice the injection of glucagon increased plasma ascorbate concentration fifteenfold, and caused a sixfold elevation of the ascorbate content of the liver. These results show that hepatic ascorbate synthesis is dependent on glycogenolysis, and indicate a regulatory role of ascorbate released by the liver. |
| doi_str_mv | 10.1016/0014-5793(94)00905-8 |
| format | Article |
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| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1994-09, Vol.352 (1), p.4-6 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Ascorbic acid Ascorbic Acid - analysis Ascorbic Acid - biosynthesis Blood Glucose - analysis Bucladesine - pharmacology Glucagon Glucagon - pharmacology Glucose - biosynthesis Glycogen Glycogen - metabolism Glycogenolysis Liver - cytology Liver - metabolism Male Mice Mouse liver |
| title | Ascorbic acid synthesis is stimulated by enhanced glycogenolysis in murine liver |
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