Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit
Seventy intensive care unit patients were admitted to a double-blind prospective study to determine the level of contamination associated with the admixture and administration of intravenous solutions and whether intravenous filtersets prevented bacteremia. Patients were randomly assigned a 0.22 mic...
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| Veröffentlicht in: | The American journal of medicine 1986-03, Vol.80 (3), p.364-368 |
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| container_title | The American journal of medicine |
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| creator | Quercia, Robert A. Hills, Sally W. Klimek, Joseph J. Mclaughlin, James C. Nightingale, Charles H. David Drezner, A. Sigman, Robert |
| description | Seventy intensive care unit patients were admitted to a double-blind prospective study to determine the level of contamination associated with the admixture and administration of intravenous solutions and whether intravenous filtersets prevented bacteremia. Patients were randomly assigned a 0.22 micron filterset (real filter) or a filter cartridge without a 0.22 micron membrane (blank filter) on all possible intravenous lines. Forty-six (14.1 percent) real filtersets and 38 (11.3 percent) blank filtersets were found to be contaminated, and overall 30 patients (42.4 percent) were found to have extrinsically contaminated intravenous administration systems at least once during the study. Bacterial adherence to the plastic cartridge was demonstrated to be responsible for culture-positive blank filtersets. Staphylococcus epidermidis was the organism most frequently isolated from real and blank filtersets. Epidemiologic surveillance identified 10 patients with blank filtersets and three patients with real filtersets with clinically significant hospital-acquired bacteremias during the study period. It is concluded that (1) a significant level of extrinsic contamination of intravenous infusion delivery systems occurred on the intensive care unit; (2) documented clinically significant nosocomial bacteremias occurred less often in those patients who had a 0.22 micron bacterial retention filter on all possible intravenous lines. |
| doi_str_mv | 10.1016/0002-9343(86)90707-2 |
| format | Article |
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Patients were randomly assigned a 0.22 micron filterset (real filter) or a filter cartridge without a 0.22 micron membrane (blank filter) on all possible intravenous lines. Forty-six (14.1 percent) real filtersets and 38 (11.3 percent) blank filtersets were found to be contaminated, and overall 30 patients (42.4 percent) were found to have extrinsically contaminated intravenous administration systems at least once during the study. Bacterial adherence to the plastic cartridge was demonstrated to be responsible for culture-positive blank filtersets. Staphylococcus epidermidis was the organism most frequently isolated from real and blank filtersets. Epidemiologic surveillance identified 10 patients with blank filtersets and three patients with real filtersets with clinically significant hospital-acquired bacteremias during the study period. It is concluded that (1) a significant level of extrinsic contamination of intravenous infusion delivery systems occurred on the intensive care unit; (2) documented clinically significant nosocomial bacteremias occurred less often in those patients who had a 0.22 micron bacterial retention filter on all possible intravenous lines.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(86)90707-2</identifier><identifier>PMID: 3513558</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Bacteriological Techniques ; Biological and medical sciences ; Cross Infection - prevention & control ; Double-Blind Method ; Emergency and intensive care: techniques, logistics ; Equipment Contamination ; Filtration - instrumentation ; Humans ; Infusions, Parenteral - instrumentation ; Infusions, Parenteral - standards ; Intensive care medicine ; Medical sciences ; Perfusions. Catheterizations. Hyperbaric oxygenotherapy ; Prospective Studies ; Random Allocation ; Sepsis - etiology ; Sepsis - prevention & control ; Solutions - standards</subject><ispartof>The American journal of medicine, 1986-03, Vol.80 (3), p.364-368</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-e2683bdf0bde1ed57851ceb4dcff967a1d406ac4483059199bf66368070d9f7f3</citedby><cites>FETCH-LOGICAL-c332t-e2683bdf0bde1ed57851ceb4dcff967a1d406ac4483059199bf66368070d9f7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002934386907072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8626253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3513558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quercia, Robert A.</creatorcontrib><creatorcontrib>Hills, Sally W.</creatorcontrib><creatorcontrib>Klimek, Joseph J.</creatorcontrib><creatorcontrib>Mclaughlin, James C.</creatorcontrib><creatorcontrib>Nightingale, Charles H.</creatorcontrib><creatorcontrib>David Drezner, A.</creatorcontrib><creatorcontrib>Sigman, Robert</creatorcontrib><title>Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Seventy intensive care unit patients were admitted to a double-blind prospective study to determine the level of contamination associated with the admixture and administration of intravenous solutions and whether intravenous filtersets prevented bacteremia. Patients were randomly assigned a 0.22 micron filterset (real filter) or a filter cartridge without a 0.22 micron membrane (blank filter) on all possible intravenous lines. Forty-six (14.1 percent) real filtersets and 38 (11.3 percent) blank filtersets were found to be contaminated, and overall 30 patients (42.4 percent) were found to have extrinsically contaminated intravenous administration systems at least once during the study. Bacterial adherence to the plastic cartridge was demonstrated to be responsible for culture-positive blank filtersets. Staphylococcus epidermidis was the organism most frequently isolated from real and blank filtersets. Epidemiologic surveillance identified 10 patients with blank filtersets and three patients with real filtersets with clinically significant hospital-acquired bacteremias during the study period. It is concluded that (1) a significant level of extrinsic contamination of intravenous infusion delivery systems occurred on the intensive care unit; (2) documented clinically significant nosocomial bacteremias occurred less often in those patients who had a 0.22 micron bacterial retention filter on all possible intravenous lines.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Bacteriological Techniques</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - prevention & control</subject><subject>Double-Blind Method</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Equipment Contamination</subject><subject>Filtration - instrumentation</subject><subject>Humans</subject><subject>Infusions, Parenteral - instrumentation</subject><subject>Infusions, Parenteral - standards</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Sepsis - etiology</subject><subject>Sepsis - prevention & control</subject><subject>Solutions - standards</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67j6DxT6IKKHXvPdyUXQRdeFBS96NaSTikS602uSHph_b9oZ5uiektT7VFF5EHpJ8BXBRL7HGNNeM87eKvlO4wEPPX2EdkQI0Q9E0sdod0aeomel_G5PrIW8QBdMECaE2qGfn6yrkOMyLb-i69ySqp1jsjUuqVtCF1PNdg9pWUu7h7VsdQ9T3EM-dOVQKsxb0tm0sZBKSzpnM3RrivU5ehLsVODF6bxEP758_n79tb_7dnN7_fGud4zR2gOVio0-4NEDAS8GJYiDkXsXgpaDJZ5jaR3nimGhidZjkJJJ1T7tdRgCu0RvjnPv8_JnhVLNHIuDabIJ2upmkAPnlOMHQcK5pINWDeRH0OWllAzB3Oc423wwBJvNv9nkmk2uUdL8829oa3t1mr-OM_hz00l4y1-fclucnUK2ycVyxpSkkgrWsA9HDJq0fYRsiouQHPiYwVXjl_j_Pf4CU9-iiQ</recordid><startdate>198603</startdate><enddate>198603</enddate><creator>Quercia, Robert A.</creator><creator>Hills, Sally W.</creator><creator>Klimek, Joseph J.</creator><creator>Mclaughlin, James C.</creator><creator>Nightingale, Charles H.</creator><creator>David Drezner, A.</creator><creator>Sigman, Robert</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198603</creationdate><title>Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit</title><author>Quercia, Robert A. ; Hills, Sally W. ; Klimek, Joseph J. ; Mclaughlin, James C. ; Nightingale, Charles H. ; David Drezner, A. ; Sigman, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-e2683bdf0bde1ed57851ceb4dcff967a1d406ac4483059199bf66368070d9f7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Bacteriological Techniques</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - prevention & control</topic><topic>Double-Blind Method</topic><topic>Emergency and intensive care: techniques, logistics</topic><topic>Equipment Contamination</topic><topic>Filtration - instrumentation</topic><topic>Humans</topic><topic>Infusions, Parenteral - instrumentation</topic><topic>Infusions, Parenteral - standards</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Sepsis - etiology</topic><topic>Sepsis - prevention & control</topic><topic>Solutions - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quercia, Robert A.</creatorcontrib><creatorcontrib>Hills, Sally W.</creatorcontrib><creatorcontrib>Klimek, Joseph J.</creatorcontrib><creatorcontrib>Mclaughlin, James C.</creatorcontrib><creatorcontrib>Nightingale, Charles H.</creatorcontrib><creatorcontrib>David Drezner, A.</creatorcontrib><creatorcontrib>Sigman, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quercia, Robert A.</au><au>Hills, Sally W.</au><au>Klimek, Joseph J.</au><au>Mclaughlin, James C.</au><au>Nightingale, Charles H.</au><au>David Drezner, A.</au><au>Sigman, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1986-03</date><risdate>1986</risdate><volume>80</volume><issue>3</issue><spage>364</spage><epage>368</epage><pages>364-368</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>Seventy intensive care unit patients were admitted to a double-blind prospective study to determine the level of contamination associated with the admixture and administration of intravenous solutions and whether intravenous filtersets prevented bacteremia. Patients were randomly assigned a 0.22 micron filterset (real filter) or a filter cartridge without a 0.22 micron membrane (blank filter) on all possible intravenous lines. Forty-six (14.1 percent) real filtersets and 38 (11.3 percent) blank filtersets were found to be contaminated, and overall 30 patients (42.4 percent) were found to have extrinsically contaminated intravenous administration systems at least once during the study. Bacterial adherence to the plastic cartridge was demonstrated to be responsible for culture-positive blank filtersets. Staphylococcus epidermidis was the organism most frequently isolated from real and blank filtersets. Epidemiologic surveillance identified 10 patients with blank filtersets and three patients with real filtersets with clinically significant hospital-acquired bacteremias during the study period. It is concluded that (1) a significant level of extrinsic contamination of intravenous infusion delivery systems occurred on the intensive care unit; (2) documented clinically significant nosocomial bacteremias occurred less often in those patients who had a 0.22 micron bacterial retention filter on all possible intravenous lines.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3513558</pmid><doi>10.1016/0002-9343(86)90707-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1986-03, Vol.80 (3), p.364-368 |
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| language | eng |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacteriological Techniques Biological and medical sciences Cross Infection - prevention & control Double-Blind Method Emergency and intensive care: techniques, logistics Equipment Contamination Filtration - instrumentation Humans Infusions, Parenteral - instrumentation Infusions, Parenteral - standards Intensive care medicine Medical sciences Perfusions. Catheterizations. Hyperbaric oxygenotherapy Prospective Studies Random Allocation Sepsis - etiology Sepsis - prevention & control Solutions - standards |
| title | Bacteriologic contamination of intravenous infusion delivery systems in an intensive care unit |
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