Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

While testing purines related to the non‐specific protein kinase inhibitors N6‐dimethylaminopurine and N6‐(2‐isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2‐(2‐hydroxyethylamino)‐6‐benzylamino‐9‐methylpurine (olomoucine)....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of biochemistry 1994-09, Vol.224 (2), p.771-786
Hauptverfasser:	Veselý, Jaroslav, Havliček, Libor, Strnad, Miroslav, Blow, J. Julian, Donella‐Deana, Arianna, Pinna, Lorenzo, Letham, David S., Kato, Jun‐ya, Detivaud, Lénaïck, Leclerc, Sophie, Meijer, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CDC2 Protein Kinase - antagonists & inhibitors Cyclins - metabolism Female Hydrogen Bonding Kinetics Molecular Structure Oocytes - enzymology Protein Kinase Inhibitors Purines - pharmacology Starfish Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!