Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment
The sensitivity of 35 adult rabbit trigeminal ganglion neurons to low pH (pH 6.0), 10 μM capsaicin (CAP) and 10 μM capsaicin at low pH (CAP@pH6.0) was studied using voltage-clamp whole-cell recording techniques. Neurons responded to pH 6.0 with a transient inward current, followed by a more slowlt a...
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| Veröffentlicht in: | Brain research 1994-07, Vol.651 (1), p.143-147 |
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| creator | Martenson, Melissa E. Ingram, Susan L. Baumann, Thomas K. |
| description | The sensitivity of 35 adult rabbit trigeminal ganglion neurons to low pH (pH 6.0), 10 μM capsaicin (CAP) and 10 μM capsaicin at low pH (CAP@pH6.0) was studied using voltage-clamp whole-cell recording techniques. Neurons responded to pH 6.0 with a transient inward current, followed by a more slowlt activating (sustained) net inward current. Responses to capsaicin showed only a sustained current. Capsaicin caused an increase in membrane conductance, whereas responses to low pH were associated with either a net increase or decrease in conductance. A subset of neurons (
n = 14) responded to CAP@pH6.0 with a sustained current which exceeded the sum of the peak sustained currents evoked by CAP and pH 6.0 applied singularly by approximately a factor of 4. The current was associated with a substantial increase in membrane conductance. The present results indicate that, in addition to a direct conductance activating effect, protons have the ability to enhance the current evoked by capsaicin. |
| doi_str_mv | 10.1016/0006-8993(94)90690-4 |
| format | Article |
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n = 14) responded to CAP@pH6.0 with a sustained current which exceeded the sum of the peak sustained currents evoked by CAP and pH 6.0 applied singularly by approximately a factor of 4. The current was associated with a substantial increase in membrane conductance. The present results indicate that, in addition to a direct conductance activating effect, protons have the ability to enhance the current evoked by capsaicin.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)90690-4</identifier><identifier>PMID: 7922561</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Capsaicin ; Capsaicin - pharmacology ; Chemosensitivity ; Electric Conductivity ; Fundamental and applied biological sciences. Psychology ; Hydrogen-Ion Concentration ; Irritant ; Isolated neuron and nerve. Neuroglia ; Male ; Neuron ; Neurons - physiology ; Patch clamp ; Proton ; Rabbits ; Sensitization ; Somatosensory ; Trigeminal Ganglion - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-07, Vol.651 (1), p.143-147</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b6ad498c0abb1930d8ec63eeb6f18b38c46be473d3f3b99a725fb8e78b0b9bea3</citedby><cites>FETCH-LOGICAL-c417t-b6ad498c0abb1930d8ec63eeb6f18b38c46be473d3f3b99a725fb8e78b0b9bea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)90690-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4151884$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7922561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martenson, Melissa E.</creatorcontrib><creatorcontrib>Ingram, Susan L.</creatorcontrib><creatorcontrib>Baumann, Thomas K.</creatorcontrib><title>Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The sensitivity of 35 adult rabbit trigeminal ganglion neurons to low pH (pH 6.0), 10 μM capsaicin (CAP) and 10 μM capsaicin at low pH (CAP@pH6.0) was studied using voltage-clamp whole-cell recording techniques. Neurons responded to pH 6.0 with a transient inward current, followed by a more slowlt activating (sustained) net inward current. Responses to capsaicin showed only a sustained current. Capsaicin caused an increase in membrane conductance, whereas responses to low pH were associated with either a net increase or decrease in conductance. A subset of neurons (
n = 14) responded to CAP@pH6.0 with a sustained current which exceeded the sum of the peak sustained currents evoked by CAP and pH 6.0 applied singularly by approximately a factor of 4. The current was associated with a substantial increase in membrane conductance. The present results indicate that, in addition to a direct conductance activating effect, protons have the ability to enhance the current evoked by capsaicin.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Chemosensitivity</subject><subject>Electric Conductivity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Irritant</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Male</subject><subject>Neuron</subject><subject>Neurons - physiology</subject><subject>Patch clamp</subject><subject>Proton</subject><subject>Rabbits</subject><subject>Sensitization</subject><subject>Somatosensory</subject><subject>Trigeminal Ganglion - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVJSLabvkEDOoTSHpxKllaWLoGytE0gkByas5DkcVCwJUfSJuTta3fNHlMQDGK--Wf4EPpMySUlVHwnhIhKKsW-Kv5NEaFIxT-gFZVNXYmakyO0OiCn6GPOT9OXMUVO0Emj6noj6Ard38cCoXhTfAw4djgZa33BJflHGHwwPU6QxxgyZFwidmbMxjsf8PQM7uMrHq8xhBefYhimpDN03Jk-w6elrtHDr59_ttfV7d3vm-2P28px2pTKCtNyJR2Z1lHFSCvBCQZgRUelZdJxYYE3rGUds0qZpt50VkIjLbHKgmFr9GWfO6b4vINc9OCzg743AeIu60Y0nHHB_wtSIeiGMjqBfA-6FHNO0Okx-cGkN02Jno3rWaeedWrF9T_jes4_X_J3doD2MLQonvoXS99kZ_oumeB8PmB8Wi7lHHO1x2CS9uIh6ew8BAetT-CKbqN__46_qNydcA</recordid><startdate>19940718</startdate><enddate>19940718</enddate><creator>Martenson, Melissa E.</creator><creator>Ingram, Susan L.</creator><creator>Baumann, Thomas K.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940718</creationdate><title>Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment</title><author>Martenson, Melissa E. ; Ingram, Susan L. ; Baumann, Thomas K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b6ad498c0abb1930d8ec63eeb6f18b38c46be473d3f3b99a725fb8e78b0b9bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Chemosensitivity</topic><topic>Electric Conductivity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Irritant</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Male</topic><topic>Neuron</topic><topic>Neurons - physiology</topic><topic>Patch clamp</topic><topic>Proton</topic><topic>Rabbits</topic><topic>Sensitization</topic><topic>Somatosensory</topic><topic>Trigeminal Ganglion - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martenson, Melissa E.</creatorcontrib><creatorcontrib>Ingram, Susan L.</creatorcontrib><creatorcontrib>Baumann, Thomas K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martenson, Melissa E.</au><au>Ingram, Susan L.</au><au>Baumann, Thomas K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-07-18</date><risdate>1994</risdate><volume>651</volume><issue>1</issue><spage>143</spage><epage>147</epage><pages>143-147</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The sensitivity of 35 adult rabbit trigeminal ganglion neurons to low pH (pH 6.0), 10 μM capsaicin (CAP) and 10 μM capsaicin at low pH (CAP@pH6.0) was studied using voltage-clamp whole-cell recording techniques. Neurons responded to pH 6.0 with a transient inward current, followed by a more slowlt activating (sustained) net inward current. Responses to capsaicin showed only a sustained current. Capsaicin caused an increase in membrane conductance, whereas responses to low pH were associated with either a net increase or decrease in conductance. A subset of neurons (
n = 14) responded to CAP@pH6.0 with a sustained current which exceeded the sum of the peak sustained currents evoked by CAP and pH 6.0 applied singularly by approximately a factor of 4. The current was associated with a substantial increase in membrane conductance. The present results indicate that, in addition to a direct conductance activating effect, protons have the ability to enhance the current evoked by capsaicin.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7922561</pmid><doi>10.1016/0006-8993(94)90690-4</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Capsaicin Capsaicin - pharmacology Chemosensitivity Electric Conductivity Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Irritant Isolated neuron and nerve. Neuroglia Male Neuron Neurons - physiology Patch clamp Proton Rabbits Sensitization Somatosensory Trigeminal Ganglion - physiology Vertebrates: nervous system and sense organs |
| title | Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment |
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