Cortisol and Alzheimer's disease, I: Basal studies
Patients with Alzheimer's disease and nondemented elderly control subjects participated in studies of cortisol secretion during sleep and at 9:00 a.m. and were given dexamethasone suppression tests (DSTs) and lumbar punctures. Nocturnal and 9:00 a.m. cortisol concentrations were significantly h...
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| Veröffentlicht in: | The American journal of psychiatry 1986-03, Vol.143 (3), p.300-305 |
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| container_title | The American journal of psychiatry |
| container_volume | 143 |
| creator | DAVIS, K. L DAVIS, B. M GREENWALD, B. S MOHS, R. C MATHE, A. A JOHNS, C. A HORVATH, T. B |
| description | Patients with Alzheimer's disease and nondemented elderly control
subjects participated in studies of cortisol secretion during sleep and at
9:00 a.m. and were given dexamethasone suppression tests (DSTs) and lumbar
punctures. Nocturnal and 9:00 a.m. cortisol concentrations were
significantly higher in the demented patients. CSF MHPG negatively
correlated with mean nocturnal cortisol. The most severely demented
patients had the highest 9:00 a.m. and mean nocturnal cortisol
concentrations. DST results did not distinguish samples with substantially
different nocturnal cortisol concentrations. These results suggest that
measurements of basal plasma cortisol concentrations and dexamethasone
suppression provide different information but support the notion of
somewhat higher than normal cortisol concentrations in Alzheimer's disease
patients. |
| doi_str_mv | 10.1176/ajp.143.3.300 |
| format | Article |
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subjects participated in studies of cortisol secretion during sleep and at
9:00 a.m. and were given dexamethasone suppression tests (DSTs) and lumbar
punctures. Nocturnal and 9:00 a.m. cortisol concentrations were
significantly higher in the demented patients. CSF MHPG negatively
correlated with mean nocturnal cortisol. The most severely demented
patients had the highest 9:00 a.m. and mean nocturnal cortisol
concentrations. DST results did not distinguish samples with substantially
different nocturnal cortisol concentrations. These results suggest that
measurements of basal plasma cortisol concentrations and dexamethasone
suppression provide different information but support the notion of
somewhat higher than normal cortisol concentrations in Alzheimer's disease
patients.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.143.3.300</identifier><identifier>PMID: 3953862</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Aged ; Alzheimer Disease - blood ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Biological and medical sciences ; Circadian Rhythm ; Dexamethasone ; Diagnosis, Differential ; Female ; Humans ; Hydrocortisone - blood ; Male ; Medical research ; Medical sciences ; Methoxyhydroxyphenylglycol - cerebrospinal fluid ; Middle Aged ; Miscellaneous ; Older people ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sleep - physiology ; Techniques and methods</subject><ispartof>The American journal of psychiatry, 1986-03, Vol.143 (3), p.300-305</ispartof><rights>1986 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Mar 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a388t-32b9d6e1839bd8f5e826b9b5b03cd98f7bd73af7f44e77c5212ea8fdfc64c1e13</citedby><cites>FETCH-LOGICAL-a388t-32b9d6e1839bd8f5e826b9b5b03cd98f7bd73af7f44e77c5212ea8fdfc64c1e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.143.3.300$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.143.3.300$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2859,21629,27869,27924,27925,77791,77792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8765129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3953862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DAVIS, K. L</creatorcontrib><creatorcontrib>DAVIS, B. M</creatorcontrib><creatorcontrib>GREENWALD, B. S</creatorcontrib><creatorcontrib>MOHS, R. C</creatorcontrib><creatorcontrib>MATHE, A. A</creatorcontrib><creatorcontrib>JOHNS, C. A</creatorcontrib><creatorcontrib>HORVATH, T. B</creatorcontrib><title>Cortisol and Alzheimer's disease, I: Basal studies</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Patients with Alzheimer's disease and nondemented elderly control
subjects participated in studies of cortisol secretion during sleep and at
9:00 a.m. and were given dexamethasone suppression tests (DSTs) and lumbar
punctures. Nocturnal and 9:00 a.m. cortisol concentrations were
significantly higher in the demented patients. CSF MHPG negatively
correlated with mean nocturnal cortisol. The most severely demented
patients had the highest 9:00 a.m. and mean nocturnal cortisol
concentrations. DST results did not distinguish samples with substantially
different nocturnal cortisol concentrations. These results suggest that
measurements of basal plasma cortisol concentrations and dexamethasone
suppression provide different information but support the notion of
somewhat higher than normal cortisol concentrations in Alzheimer's disease
patients.</description><subject>Aged</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Dexamethasone</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Methoxyhydroxyphenylglycol - cerebrospinal fluid</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Older people</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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L</au><au>DAVIS, B. M</au><au>GREENWALD, B. S</au><au>MOHS, R. C</au><au>MATHE, A. A</au><au>JOHNS, C. A</au><au>HORVATH, T. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortisol and Alzheimer's disease, I: Basal studies</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1986-03</date><risdate>1986</risdate><volume>143</volume><issue>3</issue><spage>300</spage><epage>305</epage><pages>300-305</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>Patients with Alzheimer's disease and nondemented elderly control
subjects participated in studies of cortisol secretion during sleep and at
9:00 a.m. and were given dexamethasone suppression tests (DSTs) and lumbar
punctures. Nocturnal and 9:00 a.m. cortisol concentrations were
significantly higher in the demented patients. CSF MHPG negatively
correlated with mean nocturnal cortisol. The most severely demented
patients had the highest 9:00 a.m. and mean nocturnal cortisol
concentrations. DST results did not distinguish samples with substantially
different nocturnal cortisol concentrations. These results suggest that
measurements of basal plasma cortisol concentrations and dexamethasone
suppression provide different information but support the notion of
somewhat higher than normal cortisol concentrations in Alzheimer's disease
patients.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>3953862</pmid><doi>10.1176/ajp.143.3.300</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1986-03, Vol.143 (3), p.300-305 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76742530 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Aged Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer's disease Biological and medical sciences Circadian Rhythm Dexamethasone Diagnosis, Differential Female Humans Hydrocortisone - blood Male Medical research Medical sciences Methoxyhydroxyphenylglycol - cerebrospinal fluid Middle Aged Miscellaneous Older people Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sleep - physiology Techniques and methods |
| title | Cortisol and Alzheimer's disease, I: Basal studies |
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