Fragile X chromosome frequency is consistent temporally and within replicate cultures
Fragile X frequencies differ widely between different fra(X)‐positive individuals. The basis for this variation is unknown, but may reflect genetic differences or unknown environmental factors. To determine more fully the individual and familial variation in fra(X) frequencies, we studied 15 individ...
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| Veröffentlicht in: | American journal of medical genetics 1986-01, Vol.23 (1-2), p.475-481 |
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| container_end_page | 481 |
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| container_issue | 1-2 |
| container_start_page | 475 |
| container_title | American journal of medical genetics |
| container_volume | 23 |
| creator | Jenkins, Edmund C. Kastin, Bruce R. Krawczun, Michael S. Lele, Kusum P. Silverman, Wayne P. Brown, W. Ted Opitz, John M. Reynolds, James F. |
| description | Fragile X frequencies differ widely between different fra(X)‐positive individuals. The basis for this variation is unknown, but may reflect genetic differences or unknown environmental factors. To determine more fully the individual and familial variation in fra(X) frequencies, we studied 15 individuals. The present study showed that fra(X) frequency, with few exceptions, was consistent for the same individual both over time and within replicate cultures. This confirms previous observations by others on the consistency of fra(X) expression by others, and indicates the extent of expected variability within replicate cultures. Consideration of this variability should enable improved fra(X) identification. |
| doi_str_mv | 10.1002/ajmg.1320230139 |
| format | Article |
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Consideration of this variability should enable improved fra(X) identification.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.1320230139</identifier><identifier>PMID: 3953660</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Cells, Cultured ; consistent frequency of fra(X) expression ; Cytogenetics ; Female ; fragile X ; Fragile X Syndrome - genetics ; Humans ; Lymphocytes - ultrastructure ; Male ; Martin-Bell Syndrome ; Sex Chromosome Aberrations - genetics ; Time Factors</subject><ispartof>American journal of medical genetics, 1986-01, Vol.23 (1-2), p.475-481</ispartof><rights>Copyright © 1986 Wiley‐Liss, Inc., A Wiley Company</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3829-59e309d077b21d97f9ce18d7f6f3482b9b2cb8becddc49a9bebb0ecea9c8fa013</citedby><cites>FETCH-LOGICAL-c3829-59e309d077b21d97f9ce18d7f6f3482b9b2cb8becddc49a9bebb0ecea9c8fa013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3953660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenkins, Edmund C.</creatorcontrib><creatorcontrib>Kastin, Bruce R.</creatorcontrib><creatorcontrib>Krawczun, Michael S.</creatorcontrib><creatorcontrib>Lele, Kusum P.</creatorcontrib><creatorcontrib>Silverman, Wayne P.</creatorcontrib><creatorcontrib>Brown, W. 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Consideration of this variability should enable improved fra(X) identification.</description><subject>Cells, Cultured</subject><subject>consistent frequency of fra(X) expression</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>fragile X</subject><subject>Fragile X Syndrome - genetics</subject><subject>Humans</subject><subject>Lymphocytes - ultrastructure</subject><subject>Male</subject><subject>Martin-Bell Syndrome</subject><subject>Sex Chromosome Aberrations - genetics</subject><subject>Time Factors</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQhS0EglI4c0LyiVvASxPH4gQICqgsB5aKi2U7kzaQpdiJoP8eV62KOHEaaea9NzMfQgeUHFNC2Il-rybHlDPCOKFcbqAeJTKJ0oSlm6hH6CCNBJNyB-16_04IDQ22jba5jHmSkB56vnJ6UpSAx9hOXVM1vqkA5w4-O6jtHBce26b2hW-hbnEL1axxuiznWNcZ_iraaVFjB7OysLoFbLuy7Rz4PbSV69LD_qr2w57Lp4vraPQwvLk4G0WWp0xGsQROZEaEMIxmUuTSAk0zkSc5D3caaZg1qQGbZXYgtTRgDAELWto01-HfPjpa5s5cEw72raoKb6EsdQ1N55VIxIAOSByEJ0uhdY33DnI1c0Wl3VxRohYg1QKk-gUZHIer6M5UkK31K3JhfrqcfwV68__i1Nnt3fBPerR0L8B-r93afahEcBGr1_uhiq_eyOPL-VjF_AcMmpHo</recordid><startdate>198601</startdate><enddate>198601</enddate><creator>Jenkins, Edmund C.</creator><creator>Kastin, Bruce R.</creator><creator>Krawczun, Michael S.</creator><creator>Lele, Kusum P.</creator><creator>Silverman, Wayne P.</creator><creator>Brown, W. 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This confirms previous observations by others on the consistency of fra(X) expression by others, and indicates the extent of expected variability within replicate cultures. Consideration of this variability should enable improved fra(X) identification.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3953660</pmid><doi>10.1002/ajmg.1320230139</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-7299 |
| ispartof | American journal of medical genetics, 1986-01, Vol.23 (1-2), p.475-481 |
| issn | 0148-7299 1096-8628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76741405 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cells, Cultured consistent frequency of fra(X) expression Cytogenetics Female fragile X Fragile X Syndrome - genetics Humans Lymphocytes - ultrastructure Male Martin-Bell Syndrome Sex Chromosome Aberrations - genetics Time Factors |
| title | Fragile X chromosome frequency is consistent temporally and within replicate cultures |
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