Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEV1 Fall Less Than 15 Percent
The purpose of this study is to evaluate the effect of disodium cromoglycate (DSCG) on gas exchange and ventilation during incremental exercise in asthmatic children with an FEV1 fall less than 15 percent from the baseline after the exercise. Seventeen children (aged 8 to 14 years) with a history of...
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| Veröffentlicht in: | Chest 1994-10, Vol.106 (4), p.1083-1088 |
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| creator | Baraldi, Eugenio Santuz, Pierantonio Magagnin, Giampiero Filippone, Marco Zacchello, Franco |
| description | The purpose of this study is to evaluate the effect of disodium cromoglycate (DSCG) on gas exchange and ventilation during incremental exercise in asthmatic children with an FEV1 fall less than 15 percent from the baseline after the exercise. Seventeen children (aged 8 to 14 years) with a history of mild to moderate asthma but no clinical and spirometric evidence of exercise-induced asthma (EIA) underwent two maximal exercise tests in a randomized order: test A without premedication and test B after inhalation of DSCG, 40 mg. To evaluate the effect of DSCG on normal airways, nine healthy children performed the same exercise protocol. Pulmonary function was normal at rest and after treadmill exercise test (the mean postexercise fall in FEV1 was 5.9 percent in test A and 1.5 percent in test B). Gas exchange, minute ventilation ( V˙e) and heart rate (HR) were monitored during running in both tests. In the asthmatic subjects, there were no differences in oxygen uptake ( V˙o2), carbon dioxide output ( V˙co2), and V˙e at rest between the two tests. During exercise, V˙e, V˙o2, V˙co2, and energy cost (EC [O2 ml · kg−1 · m−1]) of running in the asthmatic subjects were significantly lower in test B than in test A (analysis of variance, p |
| doi_str_mv | 10.1378/chest.106.4.1083 |
| format | Article |
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Seventeen children (aged 8 to 14 years) with a history of mild to moderate asthma but no clinical and spirometric evidence of exercise-induced asthma (EIA) underwent two maximal exercise tests in a randomized order: test A without premedication and test B after inhalation of DSCG, 40 mg. To evaluate the effect of DSCG on normal airways, nine healthy children performed the same exercise protocol. Pulmonary function was normal at rest and after treadmill exercise test (the mean postexercise fall in FEV1 was 5.9 percent in test A and 1.5 percent in test B). Gas exchange, minute ventilation ( V˙e) and heart rate (HR) were monitored during running in both tests. In the asthmatic subjects, there were no differences in oxygen uptake ( V˙o2), carbon dioxide output ( V˙co2), and V˙e at rest between the two tests. During exercise, V˙e, V˙o2, V˙co2, and energy cost (EC [O2 ml · kg−1 · m−1]) of running in the asthmatic subjects were significantly lower in test B than in test A (analysis of variance, p<0.01) for comparable work rates. Maximal minute ventilation (VEmax) was significantly higher in test A (46.9±14.6[±SD] L · min−1) than in test B (43.2±14 L · min−1; p<0.05). We found no significant effect of DSCG on gas exchange and ventilation during exercise in the healthy children ( V˙emax 47.8±25 and 48.4±25 L · min−1 in test A and B, respectively). In conclusion, premedication with DSCG appears to decrease the ventilatory cost of exercise in asthmatic children who do not present a substantial fall in FEV1 after an exercise test without pretreatment.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.106.4.1083</identifier><identifier>PMID: 7924477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Asthma ; Asthma - diagnosis ; Asthma - physiopathology ; Child ; Cromolyn Sodium - pharmacology ; disodium cromoglycate ; Energy Metabolism - drug effects ; Exercise Test ; Exercise Tolerance - drug effects ; Female ; Forced Expiratory Volume - physiology ; Heart Rate - drug effects ; Humans ; Male ; minute ventilation ; Premedication ; progressive treadmill exercise ; pulmonary gas exchange ; Pulmonary Gas Exchange - drug effects ; Spirometry</subject><ispartof>Chest, 1994-10, Vol.106 (4), p.1083-1088</ispartof><rights>1994 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-18c7a0b36f34757a27c93ed27582b6e4745f749c4844fcdb8f243820b27a8e763</citedby><cites>FETCH-LOGICAL-c301t-18c7a0b36f34757a27c93ed27582b6e4745f749c4844fcdb8f243820b27a8e763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7924477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baraldi, Eugenio</creatorcontrib><creatorcontrib>Santuz, Pierantonio</creatorcontrib><creatorcontrib>Magagnin, Giampiero</creatorcontrib><creatorcontrib>Filippone, Marco</creatorcontrib><creatorcontrib>Zacchello, Franco</creatorcontrib><title>Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEV1 Fall Less Than 15 Percent</title><title>Chest</title><addtitle>Chest</addtitle><description>The purpose of this study is to evaluate the effect of disodium cromoglycate (DSCG) on gas exchange and ventilation during incremental exercise in asthmatic children with an FEV1 fall less than 15 percent from the baseline after the exercise. Seventeen children (aged 8 to 14 years) with a history of mild to moderate asthma but no clinical and spirometric evidence of exercise-induced asthma (EIA) underwent two maximal exercise tests in a randomized order: test A without premedication and test B after inhalation of DSCG, 40 mg. To evaluate the effect of DSCG on normal airways, nine healthy children performed the same exercise protocol. Pulmonary function was normal at rest and after treadmill exercise test (the mean postexercise fall in FEV1 was 5.9 percent in test A and 1.5 percent in test B). Gas exchange, minute ventilation ( V˙e) and heart rate (HR) were monitored during running in both tests. In the asthmatic subjects, there were no differences in oxygen uptake ( V˙o2), carbon dioxide output ( V˙co2), and V˙e at rest between the two tests. During exercise, V˙e, V˙o2, V˙co2, and energy cost (EC [O2 ml · kg−1 · m−1]) of running in the asthmatic subjects were significantly lower in test B than in test A (analysis of variance, p<0.01) for comparable work rates. Maximal minute ventilation (VEmax) was significantly higher in test A (46.9±14.6[±SD] L · min−1) than in test B (43.2±14 L · min−1; p<0.05). We found no significant effect of DSCG on gas exchange and ventilation during exercise in the healthy children ( V˙emax 47.8±25 and 48.4±25 L · min−1 in test A and B, respectively). In conclusion, premedication with DSCG appears to decrease the ventilatory cost of exercise in asthmatic children who do not present a substantial fall in FEV1 after an exercise test without pretreatment.</description><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - physiopathology</subject><subject>Child</subject><subject>Cromolyn Sodium - pharmacology</subject><subject>disodium cromoglycate</subject><subject>Energy Metabolism - drug effects</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - drug effects</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>minute ventilation</subject><subject>Premedication</subject><subject>progressive treadmill exercise</subject><subject>pulmonary gas exchange</subject><subject>Pulmonary Gas Exchange - drug effects</subject><subject>Spirometry</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhS0EKkvhzgVpTtx2a8dOnHCrtrul0kr0UMrRcpzJxlViF9sp9J_wc3G7KxAHLraf9N431htC3jO6YlzWZ2bAmFaMViuRz5q_IAvWcLbkpeAvyYJSVix51RSvyZsY72jWrKlOyIlsCiGkXJBfm75Hk8D3cGGj7-w8wTr4ye_HR6MTgndwiy7ZUSeb39p1cKkjbH6aQbs9wsUcrNtnjcHYiGAdnMc0TNluYD3YsQvo4JtNA2i49jFhdj6jtptbBls9jrDDGOEm84CVcJ1BeeBb8qrXY8R3x_uUfN1ubtafl7svl1fr893ScMrSktVGatryqudCllIX0jQcu0KWddFWKKQoeykaI2ohetO1dV8IXhe0LaSuUVb8lHw8cO-D_z7nNtVko8Fx1A79HJWsJG9KWmYjPRhN8DEG7NV9sJMOj4pR9bQM9byMrCol1NMycuTDkT23E3Z_Asf2_yIHux9-2IAqTrmP7OYH2J2fg9PjP8hPhwjmTh4sBhWNRWewy3GTVOft___zG7P3q28</recordid><startdate>199410</startdate><enddate>199410</enddate><creator>Baraldi, Eugenio</creator><creator>Santuz, Pierantonio</creator><creator>Magagnin, Giampiero</creator><creator>Filippone, Marco</creator><creator>Zacchello, Franco</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199410</creationdate><title>Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEV1 Fall Less Than 15 Percent</title><author>Baraldi, Eugenio ; Santuz, Pierantonio ; Magagnin, Giampiero ; Filippone, Marco ; Zacchello, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-18c7a0b36f34757a27c93ed27582b6e4745f749c4844fcdb8f243820b27a8e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - physiopathology</topic><topic>Child</topic><topic>Cromolyn Sodium - pharmacology</topic><topic>disodium cromoglycate</topic><topic>Energy Metabolism - drug effects</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - drug effects</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>minute ventilation</topic><topic>Premedication</topic><topic>progressive treadmill exercise</topic><topic>pulmonary gas exchange</topic><topic>Pulmonary Gas Exchange - drug effects</topic><topic>Spirometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baraldi, Eugenio</creatorcontrib><creatorcontrib>Santuz, Pierantonio</creatorcontrib><creatorcontrib>Magagnin, Giampiero</creatorcontrib><creatorcontrib>Filippone, Marco</creatorcontrib><creatorcontrib>Zacchello, Franco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baraldi, Eugenio</au><au>Santuz, Pierantonio</au><au>Magagnin, Giampiero</au><au>Filippone, Marco</au><au>Zacchello, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEV1 Fall Less Than 15 Percent</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1994-10</date><risdate>1994</risdate><volume>106</volume><issue>4</issue><spage>1083</spage><epage>1088</epage><pages>1083-1088</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>The purpose of this study is to evaluate the effect of disodium cromoglycate (DSCG) on gas exchange and ventilation during incremental exercise in asthmatic children with an FEV1 fall less than 15 percent from the baseline after the exercise. Seventeen children (aged 8 to 14 years) with a history of mild to moderate asthma but no clinical and spirometric evidence of exercise-induced asthma (EIA) underwent two maximal exercise tests in a randomized order: test A without premedication and test B after inhalation of DSCG, 40 mg. To evaluate the effect of DSCG on normal airways, nine healthy children performed the same exercise protocol. Pulmonary function was normal at rest and after treadmill exercise test (the mean postexercise fall in FEV1 was 5.9 percent in test A and 1.5 percent in test B). Gas exchange, minute ventilation ( V˙e) and heart rate (HR) were monitored during running in both tests. In the asthmatic subjects, there were no differences in oxygen uptake ( V˙o2), carbon dioxide output ( V˙co2), and V˙e at rest between the two tests. During exercise, V˙e, V˙o2, V˙co2, and energy cost (EC [O2 ml · kg−1 · m−1]) of running in the asthmatic subjects were significantly lower in test B than in test A (analysis of variance, p<0.01) for comparable work rates. Maximal minute ventilation (VEmax) was significantly higher in test A (46.9±14.6[±SD] L · min−1) than in test B (43.2±14 L · min−1; p<0.05). We found no significant effect of DSCG on gas exchange and ventilation during exercise in the healthy children ( V˙emax 47.8±25 and 48.4±25 L · min−1 in test A and B, respectively). In conclusion, premedication with DSCG appears to decrease the ventilatory cost of exercise in asthmatic children who do not present a substantial fall in FEV1 after an exercise test without pretreatment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7924477</pmid><doi>10.1378/chest.106.4.1083</doi><tpages>6</tpages></addata></record> |
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| ispartof | Chest, 1994-10, Vol.106 (4), p.1083-1088 |
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| subjects | Asthma Asthma - diagnosis Asthma - physiopathology Child Cromolyn Sodium - pharmacology disodium cromoglycate Energy Metabolism - drug effects Exercise Test Exercise Tolerance - drug effects Female Forced Expiratory Volume - physiology Heart Rate - drug effects Humans Male minute ventilation Premedication progressive treadmill exercise pulmonary gas exchange Pulmonary Gas Exchange - drug effects Spirometry |
| title | Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEV1 Fall Less Than 15 Percent |
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