Anti-Idiotypic Antibody Vaccine for Type B Viral Hepatitis in Chimpanzees

Anti-idiotypic antibodies (anti-Id) that contain an internal image component that mimics the surface antigen of hepatitis B virus (HBsAg) were used to immunize chimpanzees. Four injections of the rabbit anti-Id preparation elicited an antibody response to HBsAg (anti-HBs). The antibody specificity a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-04, Vol.232 (4747), p.220-223
Hauptverfasser:	Kennedy, Ronald C., Eichberg, Jorg W., Lanford, Robert E., Dreesman, Gordon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Anti idiotypic antibodies Anti-antibodies Antibodies Antibody Formation Antigens Biological and medical sciences Chimpanzees Diseases Dosage Dose-Response Relationship, Immunologic Fundamental and applied biological sciences. Psychology Hepatitis antigens Hepatitis B Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Antibodies - immunology Hepatitis B virus Humans Immunoglobulin Idiotypes - immunology Immunoglobulins Immunologic research Immunological research Immunotherapy Infant, Newborn Infections Medical research Mice Microbiology Pan troglodytes Prevention Rabbits - immunology Rats Schistosoma mansoni - immunology Trypanosoma - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology Viruses
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