Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation

The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and GABA-mediated monosynaptic population IPSPs. These effects c...

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Veröffentlicht in:	Brain research 1994-06, Vol.647 (2), p.353-356
Hauptverfasser:	DISCENNA, P. G, FERCHMIN, P. A, ETEROVIC, V. A, TEYLER, T. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels - drug effects Central nervous system Electrophysiology Evoked Potentials - drug effects Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology GABA-A Receptor Antagonists Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Rats Receptors, AMPA - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Spermine - pharmacology Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs
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