Classification of Acid Denaturation of Proteins: Intermediates and Unfolded States

A systematic investigation of the effect of acid on the denaturation of some 20 monomeric proteins indicates that several different types of conformational behavior occur, depending on the protein, the acid, the presence of salts or denaturant, and the temperature. Three major types of effects were...

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Veröffentlicht in:	Biochemistry (Easton) 1994-10, Vol.33 (41), p.12504-12511
Hauptverfasser:	Fink, Anthony L, Calciano, Linda J, Goto, Yuji, Kurotsu, Takuzo, Palleros, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Circular Dichroism Electrochemistry Guanidine Guanidines Hydrochloric Acid Hydrogen-Ion Concentration Potassium Chloride Protein Conformation Protein Denaturation Protein Folding Proteins - chemistry Proteins - classification Temperature
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