In vivo monitoring of fluoropyrimidine metabolites: magnetic resonance spectroscopy in the evaluation of 5-fluorouracil

Since 5-fluorouracil (5-FU) was synthesized in the late 1950s it has become an important component of many anticancer treatment regimens. The increasing volume of literature accumulating about this drug is evidence that the optimal administration schedule and its combination with modulators has yet...

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Veröffentlicht in:	Anti-cancer drugs 1994-06, Vol.5 (3), p.260-280
Hauptverfasser:	Findlay, Michael PN, Leach, Martin O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clinical Trials as Topic Drug Evaluation, Preclinical Fluorine Fluorouracil - metabolism Fluorouracil - pharmacology Humans Magnetic Resonance Spectroscopy - methods Neoplasms - drug therapy Neoplasms - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Pyrimidines - metabolism Pyrimidines - pharmacology
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