5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex
The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh sele...
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Veröffentlicht in: | Neuroreport 1994-06, Vol.5 (10), p.1230-1232 |
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creator | Consolo, S Arnaboldi, S Giorgi, S Russi, G Ladinsky, H |
description | The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh selectively in the frontal cortex and were ineffective in the striatum or dorsal hippocampus. The facilitatory effect of BIMU 1 in frontal cortex was prevented by the selective 5-HT4 receptor antagonists GR 125487 and GR 113808 which by themselves did not alter basal release. The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated. 5-HT4 receptor agonists might thus offer a novel means of boosting central cholinergic function to overcome the cholinergic deficit in memory disorders. |
doi_str_mv | 10.1097/00001756-199406020-00018 |
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Both agonists, applied intracerebroventricularly, facilitated the release of ACh selectively in the frontal cortex and were ineffective in the striatum or dorsal hippocampus. The facilitatory effect of BIMU 1 in frontal cortex was prevented by the selective 5-HT4 receptor antagonists GR 125487 and GR 113808 which by themselves did not alter basal release. The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated. 5-HT4 receptor agonists might thus offer a novel means of boosting central cholinergic function to overcome the cholinergic deficit in memory disorders.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199406020-00018</identifier><identifier>PMID: 7919171</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Acetylcholine - metabolism ; Animals ; Benzimidazoles - antagonists & inhibitors ; Benzimidazoles - pharmacology ; Biological and medical sciences ; Bridged Bicyclo Compounds - antagonists & inhibitors ; Bridged Bicyclo Compounds - pharmacology ; Bridged Bicyclo Compounds, Heterocyclic ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Female ; Frontal Lobe - drug effects ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. Psychology ; Indoles - pharmacology ; Injections, Intraventricular ; Microdialysis ; Neostriatum - drug effects ; Neostriatum - metabolism ; Rats ; Serotonin Antagonists - pharmacology ; Serotonin Receptor Agonists - pharmacology ; Sulfonamides - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1994-06, Vol.5 (10), p.1230-1232</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4508-f6934b944435df6829522b837f22e1ab11736040038a5ba85622295b7ebc9c383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4206241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7919171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Consolo, S</creatorcontrib><creatorcontrib>Arnaboldi, S</creatorcontrib><creatorcontrib>Giorgi, S</creatorcontrib><creatorcontrib>Russi, G</creatorcontrib><creatorcontrib>Ladinsky, H</creatorcontrib><title>5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh selectively in the frontal cortex and were ineffective in the striatum or dorsal hippocampus. The facilitatory effect of BIMU 1 in frontal cortex was prevented by the selective 5-HT4 receptor antagonists GR 125487 and GR 113808 which by themselves did not alter basal release. The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated. 5-HT4 receptor agonists might thus offer a novel means of boosting central cholinergic function to overcome the cholinergic deficit in memory disorders.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Benzimidazoles - antagonists & inhibitors</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds - antagonists & inhibitors</subject><subject>Bridged Bicyclo Compounds - pharmacology</subject><subject>Bridged Bicyclo Compounds, Heterocyclic</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Female</subject><subject>Frontal Lobe - drug effects</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Indoles - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Microdialysis</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>Rats</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>Sulfonamides - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUuLFDEQgIMo67j6E4QcxFtr3o-jLK4rLAiygrdQna1mopnOmKRZ99_b44xzsy4FVV9VwVeEUM7ecebte7YGt9oM3HvFDBNsOFTcE7LhyspBa_f9Kdkwr_2gvNHPyYvWfqyIX6ELcmE999zyDfmqh5s7RStG3PdSaetpt2Toqcx0gphy6tCxUYjYH3PclpxmXPGM0JCmmVbodKpl7pBpLLXj75fk2QS54atTviTfrj_eXd0Mt18-fb76cDtEpZkbJuOlGr1SSur7yTjhtRCjk3YSAjmMnFtpmGJMOtAjOG2EWJnR4hh9lE5ekrfHvftafi3YetilFjFnmLEsLVhjJRPWr6A7grGW1ipOYV_TDupj4CwcdIZ_OsNZZ_ircx19fbqxjDu8Pw-e_K39N6c-tAh5qjDH1M6YEswIdcDUEXsouWNtP_PygDVsEXLfhv89U_4BHHiLSg</recordid><startdate>19940602</startdate><enddate>19940602</enddate><creator>Consolo, S</creator><creator>Arnaboldi, S</creator><creator>Giorgi, S</creator><creator>Russi, G</creator><creator>Ladinsky, H</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940602</creationdate><title>5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex</title><author>Consolo, S ; Arnaboldi, S ; Giorgi, S ; Russi, G ; Ladinsky, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4508-f6934b944435df6829522b837f22e1ab11736040038a5ba85622295b7ebc9c383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Benzimidazoles - antagonists & inhibitors</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bridged Bicyclo Compounds - antagonists & inhibitors</topic><topic>Bridged Bicyclo Compounds - pharmacology</topic><topic>Bridged Bicyclo Compounds, Heterocyclic</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Female</topic><topic>Frontal Lobe - drug effects</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Indoles - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Microdialysis</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - metabolism</topic><topic>Rats</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>Sulfonamides - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Consolo, S</creatorcontrib><creatorcontrib>Arnaboldi, S</creatorcontrib><creatorcontrib>Giorgi, S</creatorcontrib><creatorcontrib>Russi, G</creatorcontrib><creatorcontrib>Ladinsky, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Consolo, S</au><au>Arnaboldi, S</au><au>Giorgi, S</au><au>Russi, G</au><au>Ladinsky, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1994-06-02</date><risdate>1994</risdate><volume>5</volume><issue>10</issue><spage>1230</spage><epage>1232</epage><pages>1230-1232</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh selectively in the frontal cortex and were ineffective in the striatum or dorsal hippocampus. The facilitatory effect of BIMU 1 in frontal cortex was prevented by the selective 5-HT4 receptor antagonists GR 125487 and GR 113808 which by themselves did not alter basal release. The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated. 5-HT4 receptor agonists might thus offer a novel means of boosting central cholinergic function to overcome the cholinergic deficit in memory disorders.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7919171</pmid><doi>10.1097/00001756-199406020-00018</doi><tpages>3</tpages></addata></record> |
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subjects | Acetylcholine - metabolism Animals Benzimidazoles - antagonists & inhibitors Benzimidazoles - pharmacology Biological and medical sciences Bridged Bicyclo Compounds - antagonists & inhibitors Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Female Frontal Lobe - drug effects Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Indoles - pharmacology Injections, Intraventricular Microdialysis Neostriatum - drug effects Neostriatum - metabolism Rats Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Sulfonamides - pharmacology Vertebrates: nervous system and sense organs |
title | 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex |
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