5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex

The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh sele...

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Veröffentlicht in:Neuroreport 1994-06, Vol.5 (10), p.1230-1232
Hauptverfasser: Consolo, S, Arnaboldi, S, Giorgi, S, Russi, G, Ladinsky, H
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container_end_page 1232
container_issue 10
container_start_page 1230
container_title Neuroreport
container_volume 5
creator Consolo, S
Arnaboldi, S
Giorgi, S
Russi, G
Ladinsky, H
description The effect of the serotonergic 5-HT4 receptor agonists BIMU 1 and BIMU 8 on in vivo acetylcholine (ACh) release in brain hemispheric regions of freely moving rats was investigated using the microdialysis technique. Both agonists, applied intracerebroventricularly, facilitated the release of ACh selectively in the frontal cortex and were ineffective in the striatum or dorsal hippocampus. The facilitatory effect of BIMU 1 in frontal cortex was prevented by the selective 5-HT4 receptor antagonists GR 125487 and GR 113808 which by themselves did not alter basal release. The results provide the first evidence that serotonin facilitates ACh release in frontal cortex through stimulation of 5-HT4 receptors which are not tonically activated. 5-HT4 receptor agonists might thus offer a novel means of boosting central cholinergic function to overcome the cholinergic deficit in memory disorders.
doi_str_mv 10.1097/00001756-199406020-00018
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subjects Acetylcholine - metabolism
Animals
Benzimidazoles - antagonists & inhibitors
Benzimidazoles - pharmacology
Biological and medical sciences
Bridged Bicyclo Compounds - antagonists & inhibitors
Bridged Bicyclo Compounds - pharmacology
Bridged Bicyclo Compounds, Heterocyclic
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Female
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Fundamental and applied biological sciences. Psychology
Indoles - pharmacology
Injections, Intraventricular
Microdialysis
Neostriatum - drug effects
Neostriatum - metabolism
Rats
Serotonin Antagonists - pharmacology
Serotonin Receptor Agonists - pharmacology
Sulfonamides - pharmacology
Vertebrates: nervous system and sense organs
title 5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex
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