Effect of clonidine on motoneuron excitability in spinalized rats

In a dose of 0.1 mg/kg clonidine, an alpha-2 receptor agonist, depressed the spontaneous EMG activity of the biceps and quadriceps femoris in chronically-spinalized rats. It also antagonized in a dose-dependent manner the stimulating effect of 5-hydroxytryptophan (5-HTP, 100mg/kg). Doses of more tha...

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Veröffentlicht in:	Neuropharmacology 1986, Vol.25 (1), p.41-46
Hauptverfasser:	Tremblay, L.E., Bedard, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptophan Animals Anterior Horn Cells - drug effects Biological and medical sciences Catecholaminergic system clonidine Clonidine - pharmacology Decerebrate State - physiopathology Depression, Chemical Efferent Pathways - physiology Electromyography Female Medical sciences motoneurons Motor Neurons - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - physiology Pharmacology. Drug treatments Rats Rats, Inbred Strains Reflex - drug effects spinalized rats Synaptic Transmission
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