Synthesis of a Hybrid Protein Containing the Iron-Binding Ligand of Bleomycin and the DNA-Binding Domain of Hin

The iron-binding and oxygen-activating domain of the natural product bleomycin [pyrimidoblamic acid-beta-hydroxy-L-histidine (PBA-beta-OH-His)] was attached to the NH2 terminus of the DNA binding domain of Hin recombinase (residues 139-190). This hybrid 54-residue protein PBA-beta-OH-His-Hin-(139-19...

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Veröffentlicht in:	Bioconjugate chemistry 1994-05, Vol.5 (3), p.242-247
Hauptverfasser:	Oakley, Martha G, Turnbull, Kenneth D, Dervan, Peter B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Binding Sites Bleomycin - chemical synthesis Bleomycin - chemistry Bleomycin - metabolism DNA - genetics DNA - metabolism DNA Nucleotidyltransferases - chemical synthesis DNA Nucleotidyltransferases - chemistry DNA Nucleotidyltransferases - metabolism In Vitro Techniques Models, Molecular Molecular Sequence Data Molecular Structure Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - metabolism Substrate Specificity
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