HTLV-III gag Protein is Processed in Yeast Cells by the Virus pol-Protease

The gag-pol gene of HTLV-III (human T-lymphotropic virus), the virus linked to AIDS (acquired immune deficiency syndrome), was expressed in yeast, and processing of the gag precursor into proteins of the same size as those in the virion was observed. Processing of the gag gene in yeast cells mimics...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-03, Vol.231 (4745), p.1580-1584
Hauptverfasser:	Kramer, R. A., Schaber, M. D., Skalka, A. M., Ganguly, K., Wong-Staal, F., Reddy, E. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - immunology AIDS AIDS (Disease) AIDS research AIDS/HIV Antibodies Base Sequence Deltaretrovirus - enzymology Deltaretrovirus - genetics gag genes Gene Products, gag Genes, Viral Genetics HIV HIV (Viruses) Humans Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Phosphorylation Plasmids pol genes Protein precursors Protein Processing, Post-Translational Protein research Proteins Retroviridae Proteins - genetics Retroviridae Proteins - immunology Retroviridae Proteins - metabolism RNA-Directed DNA Polymerase - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Stem cells Viruses Yeast Yeast (Food product) Yeasts
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