Agonist and antagonist opioid activity of axial and equatorial conformations of S-methyl- and S-allyl-morphinans

Resolved axial (β) and equatorial (α) forms of S-methyl (β-sulforphanol, α-sulforphanol) and S-allyl (β-sulfallorphan, α-sulfallorphan) morphinans were tested for their ability to depress the electrically evoked contractions of the guinea pig ileum and of the mouse vas deferens, to compete with the...

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Veröffentlicht in:	European journal of pharmacology 1994-06, Vol.258 (1), p.111-118
Hauptverfasser:	Lemaire, Simon, Belleau, Bernard, Jolicoeur, François B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Biological and medical sciences Brain - drug effects Brain - metabolism Guinea Pigs Ileum - drug effects In Vitro Techniques Male Medical sciences Mice Morphinan Morphinans - chemistry Morphinans - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opioid receptor Pain Measurement Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Radioligand Assay Rats Receptor conformation Receptors, Opioid - drug effects Rodentia Stereoisomerism Structure-Activity Relationship Vas Deferens - drug effects
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