Block of IKs, the Slow Component of the Delayed Rectifier K+ Current, by the Diuretic Agent Indapamide in Guinea Pig Myocytes

There is a high incidence of diuretic use among patients who develop exaggerated QT prolongation and polymorphic ventricular tachycardia (torsade de pointes) during treatment with action potential-prolonging agents. Diuretic-induced hypokalemia is thought to be the usual mechanism, but a direct effe...

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Veröffentlicht in:	Circulation research 1994-11, Vol.75 (5), p.879-886
Hauptverfasser:	Turgeon, Jacques, Daleau, Pascal, Bennett, Paul B, Wiggins, S Scott, Selby, Lawrence, Roden, Dan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Chlorthalidone - pharmacology Electric Conductivity Guinea Pigs Heart Ventricles - cytology Heart Ventricles - drug effects In Vitro Techniques Indapamide - pharmacology Oocytes Potassium - physiology Potassium Channels - drug effects Potassium Channels - physiology RNA, Complementary Ventricular Function Xenopus
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