Marked decrease in trabecular bone quality after five years of sodium fluoride therapy; assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients

Sodium fluoride has for more than 2 decades been a commonly used therapeutic agent for established osteoporosis because of a repeatedly documented anabolic effect on trabecular bone mass. Recently, however, three controlled trials have failed to demonstrate any therapeutic advantage of NaF over plac...

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