Long term parenteral nutrition in the management of severe Crohn's disease

Long term parenteral nutrition in the management of severe Crohn's disease

Twelve patients with active severe Crohn's disease, who failed to respond to medical treatment, received total parenteral nutrition (T.P.N.) via a Broviac long term feeding catheter for periods of 35–190 days prior to surgery. The 10 patients who were non-oedematous increased their mean weight...

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Veröffentlicht in:Clinical nutrition (Edinburgh, Scotland) Scotland), 1985-11, Vol.4 (4), p.195-199
Hauptverfasser: Quayle, A.R., Griffith, C.D.M., Mangnall, D., Clark, R.G.
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container_title Clinical nutrition (Edinburgh, Scotland)
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Griffith, C.D.M.
Mangnall, D.
Clark, R.G.
description Twelve patients with active severe Crohn's disease, who failed to respond to medical treatment, received total parenteral nutrition (T.P.N.) via a Broviac long term feeding catheter for periods of 35–190 days prior to surgery. The 10 patients who were non-oedematous increased their mean weight by 3.3 Kg ( p
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The 10 patients who were non-oedematous increased their mean weight by 3.3 Kg ( p&lt;0.01) and their mean plasma albumin by 5.80 g/l ( p&lt;0.025) after 28 days T.P.N. There were two episodes of catheter-related sepsis. Although the mean Crohn's disease activity index was significantly reduced from 364.50 (±91.51) to 236.75 (±121.29) ( p&lt;0.005) after 28 days T.P.N., all 12 patients were found to have active disease at operation. There was no post-operative mortality and the only major post-operative morbidity was a pelvic abscess following a panproctocolectomy. 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title Long term parenteral nutrition in the management of severe Crohn's disease
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