Sodium nuclear magnetic resonance imaging of myocardial tissue of dogs after coronary artery occlusion and reperfusion
Nuclear magnetic resonance (NMR) imaging techniques have been applied to the observation of tissue sodium-23 in normal and ischemic canine myocardium. To produce a region of ischemia and infarction in the myocardium, in six dogs a coronary artery was subjected to I hour of surgical occlusion followe...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1986-03, Vol.7 (3), p.573-579 |
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| container_issue | 3 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Cannon, Paul J. Maudsley, Andrew A. Hilal, Sadek K. Simon, Howard E. Cassidy, Frederick |
| description | Nuclear magnetic resonance (NMR) imaging techniques have been applied to the observation of tissue sodium-23 in normal and ischemic canine myocardium. To produce a region of ischemia and infarction in the myocardium, in six dogs a coronary artery was subjected to I hour of surgical occlusion followed by I hour of reperfusion. The dogs were then killed and sodium-23 NMR images of the excised hearts were obtained using a high field NMR imaging system. These images were compared with tissue sodium contents measured by flame photometry. The regions of ischemic damage were clearly visible as areas of increased sodium NMR signal on the three-dimensional images. A good correspondence was found between the relative intensity of the sodium signals and the sodium contents of normal myocardium and myocardium subjected to coronary artery occlusion and reperfusion. The data suggest the feasibility of NMR sodium imaging to detect the location and extent of myocardial damage in patients with coronary artery disease. |
| doi_str_mv | 10.1016/S0735-1097(86)80467-3 |
| format | Article |
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To produce a region of ischemia and infarction in the myocardium, in six dogs a coronary artery was subjected to I hour of surgical occlusion followed by I hour of reperfusion. The dogs were then killed and sodium-23 NMR images of the excised hearts were obtained using a high field NMR imaging system. These images were compared with tissue sodium contents measured by flame photometry. The regions of ischemic damage were clearly visible as areas of increased sodium NMR signal on the three-dimensional images. A good correspondence was found between the relative intensity of the sodium signals and the sodium contents of normal myocardium and myocardium subjected to coronary artery occlusion and reperfusion. The data suggest the feasibility of NMR sodium imaging to detect the location and extent of myocardial damage in patients with coronary artery disease.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(86)80467-3</identifier><identifier>PMID: 3950237</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Arterial Occlusive Diseases - pathology ; Biological and medical sciences ; Cardiology. 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To produce a region of ischemia and infarction in the myocardium, in six dogs a coronary artery was subjected to I hour of surgical occlusion followed by I hour of reperfusion. The dogs were then killed and sodium-23 NMR images of the excised hearts were obtained using a high field NMR imaging system. These images were compared with tissue sodium contents measured by flame photometry. The regions of ischemic damage were clearly visible as areas of increased sodium NMR signal on the three-dimensional images. A good correspondence was found between the relative intensity of the sodium signals and the sodium contents of normal myocardium and myocardium subjected to coronary artery occlusion and reperfusion. The data suggest the feasibility of NMR sodium imaging to detect the location and extent of myocardial damage in patients with coronary artery disease.</description><subject>Animals</subject><subject>Arterial Occlusive Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - pathology</subject><subject>Dogs</subject><subject>Heart</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardium - pathology</subject><subject>Perfusion</subject><subject>Sodium</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVpSTdpf0JAh1Kag1vJsl6nEkJfEOgh7VnIo_GiYltbyQ7sv6_2wV57EjPzzYzmI-SWs4-ccfXpiWkhG86s_mDUnWGd0o14QTZcStMIafVLsrkgr8l1KX8YY8pwe0WuhJWsFXpDnp9SiOtE5xVG9JlOfjvjEoFmLGn2MyCNNRfnLU0DnfYJfA7Rj3SJpax4SIa0LdQPC2YKKdemvKc-13BPE8C4lphm6udQR-4wD8f4DXk1-LHg2_N7Q35__fLr4Xvz-PPbj4f7xwY6ZZcGwfYeWtMGgxj6erZiYDsFJvC2D51CLxW2wIXtmEFjDfbYSt3D0Gq0IG7I-9PcXU5_VyyLm2IBHEc_Y1qL00q3ShhZQXkCIadSMg5ul-vhee84cwff7ujbHWQ6o9zRtxO17_a8YO0nDJeus-Baf3eu-wJ-HHJVGssFM4rxylXs8wnDKuM5YnYFIlb7IWaExYUU__ORf9yin7s</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>Cannon, Paul J.</creator><creator>Maudsley, Andrew A.</creator><creator>Hilal, Sadek K.</creator><creator>Simon, Howard E.</creator><creator>Cassidy, Frederick</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860301</creationdate><title>Sodium nuclear magnetic resonance imaging of myocardial tissue of dogs after coronary artery occlusion and reperfusion</title><author>Cannon, Paul J. ; Maudsley, Andrew A. ; Hilal, Sadek K. ; Simon, Howard E. ; Cassidy, Frederick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-ec9bac282d8eedb01660c946c8d12bd46ea56e2c139408e898ebe257bcf27e9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Arterial Occlusive Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - pathology</topic><topic>Dogs</topic><topic>Heart</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardium - pathology</topic><topic>Perfusion</topic><topic>Sodium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cannon, Paul J.</creatorcontrib><creatorcontrib>Maudsley, Andrew A.</creatorcontrib><creatorcontrib>Hilal, Sadek K.</creatorcontrib><creatorcontrib>Simon, Howard E.</creatorcontrib><creatorcontrib>Cassidy, Frederick</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cannon, Paul J.</au><au>Maudsley, Andrew A.</au><au>Hilal, Sadek K.</au><au>Simon, Howard E.</au><au>Cassidy, Frederick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium nuclear magnetic resonance imaging of myocardial tissue of dogs after coronary artery occlusion and reperfusion</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>7</volume><issue>3</issue><spage>573</spage><epage>579</epage><pages>573-579</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Nuclear magnetic resonance (NMR) imaging techniques have been applied to the observation of tissue sodium-23 in normal and ischemic canine myocardium. To produce a region of ischemia and infarction in the myocardium, in six dogs a coronary artery was subjected to I hour of surgical occlusion followed by I hour of reperfusion. The dogs were then killed and sodium-23 NMR images of the excised hearts were obtained using a high field NMR imaging system. These images were compared with tissue sodium contents measured by flame photometry. The regions of ischemic damage were clearly visible as areas of increased sodium NMR signal on the three-dimensional images. A good correspondence was found between the relative intensity of the sodium signals and the sodium contents of normal myocardium and myocardium subjected to coronary artery occlusion and reperfusion. The data suggest the feasibility of NMR sodium imaging to detect the location and extent of myocardial damage in patients with coronary artery disease.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3950237</pmid><doi>10.1016/S0735-1097(86)80467-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1986-03, Vol.7 (3), p.573-579 |
| issn | 0735-1097 1558-3597 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arterial Occlusive Diseases - pathology Biological and medical sciences Cardiology. Vascular system Coronary Disease - pathology Coronary heart disease Coronary Vessels - pathology Dogs Heart Magnetic Resonance Spectroscopy - methods Medical sciences Myocardial Infarction - pathology Myocardium - pathology Perfusion Sodium |
| title | Sodium nuclear magnetic resonance imaging of myocardial tissue of dogs after coronary artery occlusion and reperfusion |
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