Activation of β‐Adrenergic Receptors Stimulates Release of an Inhibitory Transmitter from Astrocytes
: Activation of β‐adrenergic receptors on astrocytes in primary cell culture results in the release of taurine, an inhibitory transmitter. Taurine release occurs via a cyclic AMP‐mediated intracellular pathway, because (a) taurine release and intracellular cyclic AMP accumulation have similar pharma...
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| Veröffentlicht in: | Journal of neurochemistry 1986-04, Vol.46 (4), p.1298-1303 |
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| container_end_page | 1303 |
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| container_issue | 4 |
| container_start_page | 1298 |
| container_title | Journal of neurochemistry |
| container_volume | 46 |
| creator | Shain, William Madelian, Vergine Martin, David L. Kimelberg, Harold K. Perrone, Mark Lepore, Rhonda |
| description | : Activation of β‐adrenergic receptors on astrocytes in primary cell culture results in the release of taurine, an inhibitory transmitter. Taurine release occurs via a cyclic AMP‐mediated intracellular pathway, because (a) taurine release and intracellular cyclic AMP accumulation have similar pharmacologies and time courses of activation and (b) N6,O2′‐dibutyryl cyclic AMP stimulates release with a time course similar to that observed with the β‐adrenergic agonist isoproterenol. These results describe a previously unrecognized physiological function of astrocytes in the CNS—receptor‐mediated release of the neuroactive amino acid taurine. This observation indicates that astrocytes may function as local regulators of neuronal activity. |
| doi_str_mv | 10.1111/j.1471-4159.1986.tb00653.x |
| format | Article |
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Taurine release occurs via a cyclic AMP‐mediated intracellular pathway, because (a) taurine release and intracellular cyclic AMP accumulation have similar pharmacologies and time courses of activation and (b) N6,O2′‐dibutyryl cyclic AMP stimulates release with a time course similar to that observed with the β‐adrenergic agonist isoproterenol. These results describe a previously unrecognized physiological function of astrocytes in the CNS—receptor‐mediated release of the neuroactive amino acid taurine. This observation indicates that astrocytes may function as local regulators of neuronal activity.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1986.tb00653.x</identifier><identifier>PMID: 3005511</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alprenolol - pharmacology ; Animals ; Astrocytes ; Astrocytes - metabolism ; beta -adrenergic ; Biological and medical sciences ; Bucladesine - pharmacology ; Cells, Cultured ; Cyclic AMP ; Cyclic AMP - metabolism ; Epinephrine - pharmacology ; Fundamental and applied biological sciences. Psychology ; Isolated neuron and nerve. Neuroglia ; Isoproterenol - pharmacology ; Kinetics ; Norepinephrine - pharmacology ; Propranolol - pharmacology ; Rats ; Receptors, Adrenergic, beta - drug effects ; Receptors, Adrenergic, beta - physiology ; taurine ; Taurine - metabolism ; Taurine release ; Vertebrates: nervous system and sense organs ; β‐Adrenergic receptor</subject><ispartof>Journal of neurochemistry, 1986-04, Vol.46 (4), p.1298-1303</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4308-4e2160edb5476b23c0999e7d15fa831415b2da675eac3734ee344efe0f322fd93</citedby><cites>FETCH-LOGICAL-c4308-4e2160edb5476b23c0999e7d15fa831415b2da675eac3734ee344efe0f322fd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1986.tb00653.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1986.tb00653.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8791637$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3005511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shain, William</creatorcontrib><creatorcontrib>Madelian, Vergine</creatorcontrib><creatorcontrib>Martin, David L.</creatorcontrib><creatorcontrib>Kimelberg, Harold K.</creatorcontrib><creatorcontrib>Perrone, Mark</creatorcontrib><creatorcontrib>Lepore, Rhonda</creatorcontrib><title>Activation of β‐Adrenergic Receptors Stimulates Release of an Inhibitory Transmitter from Astrocytes</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Activation of β‐adrenergic receptors on astrocytes in primary cell culture results in the release of taurine, an inhibitory transmitter. Taurine release occurs via a cyclic AMP‐mediated intracellular pathway, because (a) taurine release and intracellular cyclic AMP accumulation have similar pharmacologies and time courses of activation and (b) N6,O2′‐dibutyryl cyclic AMP stimulates release with a time course similar to that observed with the β‐adrenergic agonist isoproterenol. These results describe a previously unrecognized physiological function of astrocytes in the CNS—receptor‐mediated release of the neuroactive amino acid taurine. This observation indicates that astrocytes may function as local regulators of neuronal activity.</description><subject>Alprenolol - pharmacology</subject><subject>Animals</subject><subject>Astrocytes</subject><subject>Astrocytes - metabolism</subject><subject>beta -adrenergic</subject><subject>Biological and medical sciences</subject><subject>Bucladesine - pharmacology</subject><subject>Cells, Cultured</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Epinephrine - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Isoproterenol - pharmacology</subject><subject>Kinetics</subject><subject>Norepinephrine - pharmacology</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Receptors, Adrenergic, beta - drug effects</subject><subject>Receptors, Adrenergic, beta - physiology</subject><subject>taurine</subject><subject>Taurine - metabolism</subject><subject>Taurine release</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>β‐Adrenergic receptor</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcuKFDEYhYMoY9v6CEIh4q7K3FPlRprGy8igoOM6pFJ_xjR1aZO0Tu98BJ_FB_EhfBJTdNFbMZtAzneS_Ocg9ITgiuT1fFcRrkjJiWgq0tSySi3GUrDq9g5anaW7aIUxpSXDnN5HD2LcYUwkl-QCXTCMhSBkhW42NvlvJvlpLCZX_P7158fPTRdghHDjbfERLOzTFGLxKfnh0JsEMR_2YCLMvBmLy_GLb31mjsV1MGMcfEoQChemodjEFCZ7zKaH6J4zfYRHy75Gn1-_ut6-La8-vLncbq5KyxmuSw6USAxdK7iSLWUWN00DqiPCmZqRPFZLOyOVAGOZYhyAcQ4OsGOUuq5ha_TsdO8-TF8PEJMefLTQ92aE6RC1kopKKsQ_QcKZ4hizDL44gTZMMQZweh_8YMJRE6znOvROz5nrOXM916GXOvRtNj9eXjm0A3Rn65J_1p8uuonW9C4HaH08Y7VqiMxzrtHLE_bd93D8jw_od--3hDY1-wsZ2qnY</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>Shain, William</creator><creator>Madelian, Vergine</creator><creator>Martin, David L.</creator><creator>Kimelberg, Harold K.</creator><creator>Perrone, Mark</creator><creator>Lepore, Rhonda</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>Activation of β‐Adrenergic Receptors Stimulates Release of an Inhibitory Transmitter from Astrocytes</title><author>Shain, William ; Madelian, Vergine ; Martin, David L. ; Kimelberg, Harold K. ; Perrone, Mark ; Lepore, Rhonda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4308-4e2160edb5476b23c0999e7d15fa831415b2da675eac3734ee344efe0f322fd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Alprenolol - pharmacology</topic><topic>Animals</topic><topic>Astrocytes</topic><topic>Astrocytes - metabolism</topic><topic>beta -adrenergic</topic><topic>Biological and medical sciences</topic><topic>Bucladesine - pharmacology</topic><topic>Cells, Cultured</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Epinephrine - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Isoproterenol - pharmacology</topic><topic>Kinetics</topic><topic>Norepinephrine - pharmacology</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Receptors, Adrenergic, beta - drug effects</topic><topic>Receptors, Adrenergic, beta - physiology</topic><topic>taurine</topic><topic>Taurine - metabolism</topic><topic>Taurine release</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>β‐Adrenergic receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shain, William</creatorcontrib><creatorcontrib>Madelian, Vergine</creatorcontrib><creatorcontrib>Martin, David L.</creatorcontrib><creatorcontrib>Kimelberg, Harold K.</creatorcontrib><creatorcontrib>Perrone, Mark</creatorcontrib><creatorcontrib>Lepore, Rhonda</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shain, William</au><au>Madelian, Vergine</au><au>Martin, David L.</au><au>Kimelberg, Harold K.</au><au>Perrone, Mark</au><au>Lepore, Rhonda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of β‐Adrenergic Receptors Stimulates Release of an Inhibitory Transmitter from Astrocytes</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1986-04</date><risdate>1986</risdate><volume>46</volume><issue>4</issue><spage>1298</spage><epage>1303</epage><pages>1298-1303</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Activation of β‐adrenergic receptors on astrocytes in primary cell culture results in the release of taurine, an inhibitory transmitter. Taurine release occurs via a cyclic AMP‐mediated intracellular pathway, because (a) taurine release and intracellular cyclic AMP accumulation have similar pharmacologies and time courses of activation and (b) N6,O2′‐dibutyryl cyclic AMP stimulates release with a time course similar to that observed with the β‐adrenergic agonist isoproterenol. These results describe a previously unrecognized physiological function of astrocytes in the CNS—receptor‐mediated release of the neuroactive amino acid taurine. This observation indicates that astrocytes may function as local regulators of neuronal activity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3005511</pmid><doi>10.1111/j.1471-4159.1986.tb00653.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of neurochemistry, 1986-04, Vol.46 (4), p.1298-1303 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76726255 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alprenolol - pharmacology Animals Astrocytes Astrocytes - metabolism beta -adrenergic Biological and medical sciences Bucladesine - pharmacology Cells, Cultured Cyclic AMP Cyclic AMP - metabolism Epinephrine - pharmacology Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Isoproterenol - pharmacology Kinetics Norepinephrine - pharmacology Propranolol - pharmacology Rats Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - physiology taurine Taurine - metabolism Taurine release Vertebrates: nervous system and sense organs β‐Adrenergic receptor |
| title | Activation of β‐Adrenergic Receptors Stimulates Release of an Inhibitory Transmitter from Astrocytes |
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