Interleukin-1 receptor antagonist protein inhibits the synthesis of IgE and proinflammatory cytokines by allergen-stimulated mononuclear cells

The ability of interleukin-1 (IL-1) to activate diverse cell populations supports its role as a preeminent cytokine in the pathogenesis of chronic inflammation. In this study, we investigated the role of Il-1 and IL-1 receptor antagonist protein (IRAP) in the regulation of allergen-induced synthesis...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1994-10, Vol.11 (4), p.473-479
Hauptverfasser:	Sim, TC, Hilsmeier, KA, Reece, LM, Grant, JA, Alam, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - adverse effects Allergens - immunology Asthma - blood Asthma - immunology Cells, Cultured Cytokines - antagonists & inhibitors Cytokines - biosynthesis Enzyme-Linked Immunosorbent Assay Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Immunoglobulin E - biosynthesis Interleukin 1 Receptor Antagonist Protein Interleukin-1 - metabolism Interleukin-1 - pharmacology Interleukin-6 - antagonists & inhibitors Interleukin-6 - biosynthesis Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Receptors, IgE - biosynthesis Receptors, IgE - drug effects Receptors, Interleukin-1 - antagonists & inhibitors Recombinant Proteins - metabolism Sialoglycoproteins - metabolism Sialoglycoproteins - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis
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