AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus

AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over fli...

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Veröffentlicht in:	Neuroreport 1994-06, Vol.5 (11), p.1325-1328
Hauptverfasser:	Eastwood, Sharon L, Burnet, Philip W. J, Beckwith, Jason, Kerwin, Robert W, Harrison, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Hippocampus - ultrastructure Humans Middle Aged Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Rats Receptors, AMPA - biosynthesis Receptors, AMPA - genetics RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Species Specificity Vertebrates: nervous system and sense organs
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