The effect of acidosis on the labelling of urinary ammonia during infusion of [amide-15N]glutamine in human subjects

In three experiments [amide-15N]glutamine was infused intravenously in male volunteers. After 4–8 h of infusion acidosis was achieved by an oral dose of CaCl2 (1 mmol/kg). In one subject acidosis was maintained for 5 d. The acid load produced an approximately 3-fold increase in urinary NH3 excretion...

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