The effect of acidosis on the labelling of urinary ammonia during infusion of [amide-15N]glutamine in human subjects
In three experiments [amide-15N]glutamine was infused intravenously in male volunteers. After 4–8 h of infusion acidosis was achieved by an oral dose of CaCl2 (1 mmol/kg). In one subject acidosis was maintained for 5 d. The acid load produced an approximately 3-fold increase in urinary NH3 excretion...
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| Veröffentlicht in: | British journal of nutrition 1994-07, Vol.72 (1), p.83-92 |
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| container_title | British journal of nutrition |
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| creator | Waterlow, J. C. Jackson, A. A. Golden, M. H. N. Jahoor, F. Sutton, G. Fern, E. B. |
| description | In three experiments [amide-15N]glutamine was infused intravenously in male volunteers. After 4–8 h of infusion acidosis was achieved by an oral dose of CaCl2 (1 mmol/kg). In one subject acidosis was maintained for 5 d. The acid load produced an approximately 3-fold increase in urinary NH3 excretion, with a small (approximately 20%) and transient increase in the isotope abundance of urinary NH3 Estimates of glutamine production rate (flux) were obtained in two experiments. There was no evidence that it was increased in acidosis. The extra NH3 production by the kidney represented only a very small part, about 3%, of the total glutamine production rate. |
| doi_str_mv | 10.1079/BJN19940011 |
| format | Article |
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The extra NH3 production by the kidney represented only a very small part, about 3%, of the total glutamine production rate.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19940011</identifier><identifier>PMID: 7918331</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acidosis ; Acidosis - metabolism ; Adult ; Aged ; amino acid metabolism ; ammonia ; Ammonia - urine ; Calcium Chloride - administration & dosage ; glutamine ; Glutamine - administration & dosage ; Glutamine - metabolism ; Humans ; infusion ; Infusions, Intravenous ; Isotope Labeling ; Kidney - metabolism ; Labelling of urinary ammonia in glutamine infusion ; Male ; men ; Nitrogen Isotopes ; Pilot Projects ; Urinary ammonia ; urine</subject><ispartof>British journal of nutrition, 1994-07, Vol.72 (1), p.83-92</ispartof><rights>Copyright © The Nutrition Society 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-b585731ef496051bcf3d101bccc6cd95e867fd420f2858bf64afb9acc2bf011d3</citedby><cites>FETCH-LOGICAL-c421t-b585731ef496051bcf3d101bccc6cd95e867fd420f2858bf64afb9acc2bf011d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7918331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waterlow, J. C.</creatorcontrib><creatorcontrib>Jackson, A. A.</creatorcontrib><creatorcontrib>Golden, M. H. N.</creatorcontrib><creatorcontrib>Jahoor, F.</creatorcontrib><creatorcontrib>Sutton, G.</creatorcontrib><creatorcontrib>Fern, E. B.</creatorcontrib><title>The effect of acidosis on the labelling of urinary ammonia during infusion of [amide-15N]glutamine in human subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>In three experiments [amide-15N]glutamine was infused intravenously in male volunteers. After 4–8 h of infusion acidosis was achieved by an oral dose of CaCl2 (1 mmol/kg). In one subject acidosis was maintained for 5 d. The acid load produced an approximately 3-fold increase in urinary NH3 excretion, with a small (approximately 20%) and transient increase in the isotope abundance of urinary NH3 Estimates of glutamine production rate (flux) were obtained in two experiments. There was no evidence that it was increased in acidosis. The extra NH3 production by the kidney represented only a very small part, about 3%, of the total glutamine production rate.</description><subject>Acidosis</subject><subject>Acidosis - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>amino acid metabolism</subject><subject>ammonia</subject><subject>Ammonia - urine</subject><subject>Calcium Chloride - administration & dosage</subject><subject>glutamine</subject><subject>Glutamine - administration & dosage</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>infusion</subject><subject>Infusions, Intravenous</subject><subject>Isotope Labeling</subject><subject>Kidney - metabolism</subject><subject>Labelling of urinary ammonia in glutamine infusion</subject><subject>Male</subject><subject>men</subject><subject>Nitrogen Isotopes</subject><subject>Pilot Projects</subject><subject>Urinary ammonia</subject><subject>urine</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1v1DAQxS0EKtvCiTPCJy5VwJP4Iz5CgS1QFaG2qBJCluPYqZfELnYiwX-PV7taceA0Gr-f38w8hJ4BeQVEyNdvP12ClJQQgAdoBVSwqua8fohWhBBRAVD2GB3nvCltC0QeoSMhoW0aWKH5-s5i65w1M44Oa-P7mH3GMeC5KKPu7Dj6MGzFJfmg0x-spykGr3G_fRiwD27JvnwoyHc9-d5WwC5_DOMyly7YAuC7ZdIB56XblEH5CXrk9Jjt0309QTcf3l-fnVcXX9Yfz95cVIbWMFcda5lowDoqOWHQGdf0QEo1hpteMtty4XpaE1e3rO0cp9p1UhtTd65k0Tcn6OXO9z7FX4vNs5p8NuUgHWxcshJc1JQwWcDTHWhSzDlZp-6Tn8qtCojaZqz-ybjQz_e2SzfZ_sDuQy16tdN9nu3vg6zTT8VFI5ji66_q87er89vbd2u1nf5ixzsdlR6Sz-rmqibQEKCyISWDg6PRU5d8P1i1iUsKJbz_bvgXxfiehw</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Waterlow, J. 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C.</creatorcontrib><creatorcontrib>Jackson, A. A.</creatorcontrib><creatorcontrib>Golden, M. H. N.</creatorcontrib><creatorcontrib>Jahoor, F.</creatorcontrib><creatorcontrib>Sutton, G.</creatorcontrib><creatorcontrib>Fern, E. B.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waterlow, J. C.</au><au>Jackson, A. A.</au><au>Golden, M. H. N.</au><au>Jahoor, F.</au><au>Sutton, G.</au><au>Fern, E. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of acidosis on the labelling of urinary ammonia during infusion of [amide-15N]glutamine in human subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>72</volume><issue>1</issue><spage>83</spage><epage>92</epage><pages>83-92</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>In three experiments [amide-15N]glutamine was infused intravenously in male volunteers. After 4–8 h of infusion acidosis was achieved by an oral dose of CaCl2 (1 mmol/kg). In one subject acidosis was maintained for 5 d. The acid load produced an approximately 3-fold increase in urinary NH3 excretion, with a small (approximately 20%) and transient increase in the isotope abundance of urinary NH3 Estimates of glutamine production rate (flux) were obtained in two experiments. There was no evidence that it was increased in acidosis. The extra NH3 production by the kidney represented only a very small part, about 3%, of the total glutamine production rate.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>7918331</pmid><doi>10.1079/BJN19940011</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 1994-07, Vol.72 (1), p.83-92 |
| issn | 0007-1145 1475-2662 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Acidosis Acidosis - metabolism Adult Aged amino acid metabolism ammonia Ammonia - urine Calcium Chloride - administration & dosage glutamine Glutamine - administration & dosage Glutamine - metabolism Humans infusion Infusions, Intravenous Isotope Labeling Kidney - metabolism Labelling of urinary ammonia in glutamine infusion Male men Nitrogen Isotopes Pilot Projects Urinary ammonia urine |
| title | The effect of acidosis on the labelling of urinary ammonia during infusion of [amide-15N]glutamine in human subjects |
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