GLYCOPEPTIDE ANTIBIOTICS: A MECHANISM-BASED SCREEN EMPLOYING A BACTERIAL CELL WALL RECEPTOR MIMETIC

The evolution of a highly targeted screening program for the discovery of antibiotics of the glycopeptide (vancomycin) class is described. A holistic approach was utilized which optimized not just screening techniques but also the selection of candidate producer cultures and their growth under condi...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(1), pp.58-67
Hauptverfasser:	RAKE, J. B., GERBER, R., MEHTA, R. J., NEWMAN, D. J., OH, Y. K., PHELEN, C., SHEARER, M. C., SITRIN, R. D., NISBET, L. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - analysis Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Cell Wall - drug effects Drug Resistance, Microbial False Positive Reactions Fundamental and applied biological sciences. Psychology Glycopeptides - pharmacology Methods Microbial Sensitivity Tests Microbiology Vancomycin - pharmacology
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