Phosphatidylcholine-Specific Phospholipase D Activity Is Elevated in v-Fps-Transformed Cells

Activating the protein-tyrosine kinase of v-Fps results in a rapid increase in diglyceride (DG) in rat fibroblasts. The v-Fps-induced increases in DG were detected only when phospholipids were prelabeled with [3H]-myristate, which is incorporated primarily into phosphatidylcholine (PC). Inhibition o...

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Veröffentlicht in:	Biochemical and biophysical research communications 1994-09, Vol.203 (2), p.1195-1203
Hauptverfasser:	Jiang, Y.W., Song, J.G., Zang, Q., Foster, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Cell Line, Transformed Diglycerides - metabolism Enzyme Activation Fibroblasts - metabolism Fusion Proteins, gag-onc - pharmacology Myristic Acid Myristic Acids - metabolism Phosphatidate Phosphatase - antagonists & inhibitors Phosphatidic Acids - metabolism Phosphatidylcholines - metabolism Phospholipase D - metabolism Propranolol - pharmacology Protein-Tyrosine Kinases - metabolism Rats Temperature
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