Immune-induced vascular connective tissue alterations in rabbits chronically immunized with bovine serum albumin: Biochemical studies on collagen, glycosaminoglycans, RNA, and DNA in normal and injured aorta
Repeated intravenous injections of bovine serum albumin in rabbits caused a significant reduction in the aortic in vivo biosynthesis of chondroitin-4,6-sulfate, whereas no changes were observed in the synthesis of other glycosaminoglycans nor in the content of collagen. This contrasts the biochemica...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1986-04, Vol.39 (1), p.1-13 |
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| creator | Jensen, Bjarne A. Garbarsch, Charly Kappelgaard, Ellen Lorenzen, Ib |
| description | Repeated intravenous injections of bovine serum albumin in rabbits caused a significant reduction in the aortic
in vivo biosynthesis of chondroitin-4,6-sulfate, whereas no changes were observed in the synthesis of other glycosaminoglycans nor in the content of collagen. This contrasts the biochemical changes generally seen in acute vascular injury. When experimentally elicited vascular injury and repair processes were induced in chronically immunized rabbits, the proliferative response was greatly inhibited, as reflected by a significant diminution of the DNA amount. Also, the vascular connective tissue matrix repair was restrained: the aortic content of collagen and the collagen type
III
I
ratio was repressed, and the
in vivo biosynthesis of sulfated glycosaminoglycans was markedly reduced. All immunized rabbits developed antibodies to bovine albumin, but in only a few were circulating immune complexes detected. The inhibitory effect of persistent immunostimulation on the nonspecific processes of repair in vascular connective tissue may be of significance as to chronicity of vasculitis, as well as inflammation and repair in general, in inflammatory connective tissue diseases. |
| doi_str_mv | 10.1016/0090-1229(86)90200-X |
| format | Article |
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in vivo biosynthesis of chondroitin-4,6-sulfate, whereas no changes were observed in the synthesis of other glycosaminoglycans nor in the content of collagen. This contrasts the biochemical changes generally seen in acute vascular injury. When experimentally elicited vascular injury and repair processes were induced in chronically immunized rabbits, the proliferative response was greatly inhibited, as reflected by a significant diminution of the DNA amount. Also, the vascular connective tissue matrix repair was restrained: the aortic content of collagen and the collagen type
III
I
ratio was repressed, and the
in vivo biosynthesis of sulfated glycosaminoglycans was markedly reduced. All immunized rabbits developed antibodies to bovine albumin, but in only a few were circulating immune complexes detected. The inhibitory effect of persistent immunostimulation on the nonspecific processes of repair in vascular connective tissue may be of significance as to chronicity of vasculitis, as well as inflammation and repair in general, in inflammatory connective tissue diseases.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(86)90200-X</identifier><identifier>PMID: 2419018</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Aorta - immunology ; Aorta - injuries ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Collagen - metabolism ; Connective Tissue - immunology ; Connective Tissue - metabolism ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; DNA - metabolism ; Glycosaminoglycans - metabolism ; Hydroxyproline - analysis ; Male ; Medical sciences ; Rabbits ; RNA - metabolism ; Serum Albumin, Bovine - immunology</subject><ispartof>Clinical immunology and immunopathology, 1986-04, Vol.39 (1), p.1-13</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b26f043384ad4f500a98690d7701c1ea05bc32f45854c90e549e696d688f798c3</citedby><cites>FETCH-LOGICAL-c386t-b26f043384ad4f500a98690d7701c1ea05bc32f45854c90e549e696d688f798c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8651409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2419018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, Bjarne A.</creatorcontrib><creatorcontrib>Garbarsch, Charly</creatorcontrib><creatorcontrib>Kappelgaard, Ellen</creatorcontrib><creatorcontrib>Lorenzen, Ib</creatorcontrib><title>Immune-induced vascular connective tissue alterations in rabbits chronically immunized with bovine serum albumin: Biochemical studies on collagen, glycosaminoglycans, RNA, and DNA in normal and injured aorta</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Repeated intravenous injections of bovine serum albumin in rabbits caused a significant reduction in the aortic
in vivo biosynthesis of chondroitin-4,6-sulfate, whereas no changes were observed in the synthesis of other glycosaminoglycans nor in the content of collagen. This contrasts the biochemical changes generally seen in acute vascular injury. When experimentally elicited vascular injury and repair processes were induced in chronically immunized rabbits, the proliferative response was greatly inhibited, as reflected by a significant diminution of the DNA amount. Also, the vascular connective tissue matrix repair was restrained: the aortic content of collagen and the collagen type
III
I
ratio was repressed, and the
in vivo biosynthesis of sulfated glycosaminoglycans was markedly reduced. All immunized rabbits developed antibodies to bovine albumin, but in only a few were circulating immune complexes detected. The inhibitory effect of persistent immunostimulation on the nonspecific processes of repair in vascular connective tissue may be of significance as to chronicity of vasculitis, as well as inflammation and repair in general, in inflammatory connective tissue diseases.</description><subject>Animals</subject><subject>Aorta - immunology</subject><subject>Aorta - injuries</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Collagen - metabolism</subject><subject>Connective Tissue - immunology</subject><subject>Connective Tissue - metabolism</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>DNA - metabolism</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Hydroxyproline - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rabbits</subject><subject>RNA - metabolism</subject><subject>Serum Albumin, Bovine - immunology</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-K1DAUxoso67r6Bgq5EFGY6kmbpokXwrj-W1hWEIW9C2l6upOlTdakGRlf0lcydYa59CrhnO_7zkl-RfGUwmsKlL8BkFDSqpIvBX8loQIor-8Vp3QpVzWj94vTo-Rh8SjGWwDgDNqT4qRiVAIVp8Wfi2lKDkvr-mSwJ1sdTRp1IMY7h2a2WySzjTEh0eOMQc_Wu0isI0F3nZ0jMZvgnTV6HHfELmH2d875ZecN6fzWOiQRQ5qyvUuTdW_Je-vNBqfFQuKceouReJcHjqO-QbciN-PO-Kiz2C9X7eKKfLtar4h2PflwtV6mOx-m7F8q1t2mkEdqH2b9uHgw6DHik8N5Vvz49PH7-Zfy8uvni_P1ZWlqweeyq_gArK4F0z0bGgAtBZfQty1QQ1FD05m6GlgjGmYkYMMkcsl7LsTQSmHqs-LFPvcu-J8J46wmGw3mJzj0KaqWtxkINFnI9kITfIwBB3UX7KTDTlFQC0e1QFILJCW4-sdRXWfbs0N-6ibsj6YDuNx_fuhnYHocgnbGxqNM8IYykFn2bi_D_Bdbi0FFY9Fl0jZkuqr39v97_AVXJ72R</recordid><startdate>19860401</startdate><enddate>19860401</enddate><creator>Jensen, Bjarne A.</creator><creator>Garbarsch, Charly</creator><creator>Kappelgaard, Ellen</creator><creator>Lorenzen, Ib</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860401</creationdate><title>Immune-induced vascular connective tissue alterations in rabbits chronically immunized with bovine serum albumin: Biochemical studies on collagen, glycosaminoglycans, RNA, and DNA in normal and injured aorta</title><author>Jensen, Bjarne A. ; Garbarsch, Charly ; Kappelgaard, Ellen ; Lorenzen, Ib</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b26f043384ad4f500a98690d7701c1ea05bc32f45854c90e549e696d688f798c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Aorta - immunology</topic><topic>Aorta - injuries</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Collagen - metabolism</topic><topic>Connective Tissue - immunology</topic><topic>Connective Tissue - metabolism</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>DNA - metabolism</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Hydroxyproline - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rabbits</topic><topic>RNA - metabolism</topic><topic>Serum Albumin, Bovine - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Jensen, Bjarne A.</creatorcontrib><creatorcontrib>Garbarsch, Charly</creatorcontrib><creatorcontrib>Kappelgaard, Ellen</creatorcontrib><creatorcontrib>Lorenzen, Ib</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, Bjarne A.</au><au>Garbarsch, Charly</au><au>Kappelgaard, Ellen</au><au>Lorenzen, Ib</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune-induced vascular connective tissue alterations in rabbits chronically immunized with bovine serum albumin: Biochemical studies on collagen, glycosaminoglycans, RNA, and DNA in normal and injured aorta</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>39</volume><issue>1</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Repeated intravenous injections of bovine serum albumin in rabbits caused a significant reduction in the aortic
in vivo biosynthesis of chondroitin-4,6-sulfate, whereas no changes were observed in the synthesis of other glycosaminoglycans nor in the content of collagen. This contrasts the biochemical changes generally seen in acute vascular injury. When experimentally elicited vascular injury and repair processes were induced in chronically immunized rabbits, the proliferative response was greatly inhibited, as reflected by a significant diminution of the DNA amount. Also, the vascular connective tissue matrix repair was restrained: the aortic content of collagen and the collagen type
III
I
ratio was repressed, and the
in vivo biosynthesis of sulfated glycosaminoglycans was markedly reduced. All immunized rabbits developed antibodies to bovine albumin, but in only a few were circulating immune complexes detected. The inhibitory effect of persistent immunostimulation on the nonspecific processes of repair in vascular connective tissue may be of significance as to chronicity of vasculitis, as well as inflammation and repair in general, in inflammatory connective tissue diseases.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>2419018</pmid><doi>10.1016/0090-1229(86)90200-X</doi><tpages>13</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1986-04, Vol.39 (1), p.1-13 |
| issn | 0090-1229 1090-2341 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Aorta - immunology Aorta - injuries Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Collagen - metabolism Connective Tissue - immunology Connective Tissue - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous DNA - metabolism Glycosaminoglycans - metabolism Hydroxyproline - analysis Male Medical sciences Rabbits RNA - metabolism Serum Albumin, Bovine - immunology |
| title | Immune-induced vascular connective tissue alterations in rabbits chronically immunized with bovine serum albumin: Biochemical studies on collagen, glycosaminoglycans, RNA, and DNA in normal and injured aorta |
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