Keratoacanthoma and squamous cell carcinoma of the skin: Immunohistochemical localization of involucrin and keratin proteins
Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1986-02, Vol.14 (2), p.226-234 |
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| creator | Smoller, Bruce R. Kwan, Theodore H. Said, Jonathan W. Banks-Schlegel, Susan |
| description | Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild to moderate intensity. Squamous cell carcinomas disclosed a highly irregular involucrin staining pattern with marked variation in staining intensity from cell to cell. Staining patterns for keratin proteins did not appear to distinguish between keratoacanthomas and squamous cell carcinomas. The 45-kilodalton keratin pattern showed diffuse staining within both keratoacanthomas and squamous cell carcinomas, and the 63-kilodalton keratin pattern consisted of focal staining, mostly of dyskeratotic cells. These results suggest that involucrin may serve as a diagnostic aid in differentiating between squamous cell carcinomas and keratoacanthomas. In addition, other lesions in the differential diagnosis of keratoacanthoma and squamous cell carcinoma were also examined for involucrin. |
| doi_str_mv | 10.1016/S0190-9622(86)70026-1 |
| format | Article |
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Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild to moderate intensity. Squamous cell carcinomas disclosed a highly irregular involucrin staining pattern with marked variation in staining intensity from cell to cell. Staining patterns for keratin proteins did not appear to distinguish between keratoacanthomas and squamous cell carcinomas. The 45-kilodalton keratin pattern showed diffuse staining within both keratoacanthomas and squamous cell carcinomas, and the 63-kilodalton keratin pattern consisted of focal staining, mostly of dyskeratotic cells. These results suggest that involucrin may serve as a diagnostic aid in differentiating between squamous cell carcinomas and keratoacanthomas. In addition, other lesions in the differential diagnosis of keratoacanthoma and squamous cell carcinoma were also examined for involucrin.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(86)70026-1</identifier><identifier>PMID: 2419374</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Squamous Cell - analysis ; Dermatology ; Epidermis - analysis ; Histocytochemistry ; Humans ; Immunoenzyme Techniques ; Keratins - analysis ; Keratoacanthoma - metabolism ; Medical sciences ; Middle Aged ; Neoplasm Proteins - analysis ; Protein Precursors - analysis ; Sebaceous Glands - analysis ; Skin Diseases - metabolism ; Skin Neoplasms - analysis ; Sweat Glands - analysis ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of the American Academy of Dermatology, 1986-02, Vol.14 (2), p.226-234</ispartof><rights>1986 American Academy of Dermatology, Inc.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-61037c09472280d97ead3ce86c861f746b7726599e76351220abffcc8ecce99f3</citedby><cites>FETCH-LOGICAL-c455t-61037c09472280d97ead3ce86c861f746b7726599e76351220abffcc8ecce99f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0190-9622(86)70026-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8557902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2419374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smoller, Bruce R.</creatorcontrib><creatorcontrib>Kwan, Theodore H.</creatorcontrib><creatorcontrib>Said, Jonathan W.</creatorcontrib><creatorcontrib>Banks-Schlegel, Susan</creatorcontrib><title>Keratoacanthoma and squamous cell carcinoma of the skin: Immunohistochemical localization of involucrin and keratin proteins</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild to moderate intensity. Squamous cell carcinomas disclosed a highly irregular involucrin staining pattern with marked variation in staining intensity from cell to cell. Staining patterns for keratin proteins did not appear to distinguish between keratoacanthomas and squamous cell carcinomas. The 45-kilodalton keratin pattern showed diffuse staining within both keratoacanthomas and squamous cell carcinomas, and the 63-kilodalton keratin pattern consisted of focal staining, mostly of dyskeratotic cells. These results suggest that involucrin may serve as a diagnostic aid in differentiating between squamous cell carcinomas and keratoacanthomas. In addition, other lesions in the differential diagnosis of keratoacanthoma and squamous cell carcinoma were also examined for involucrin.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - analysis</subject><subject>Dermatology</subject><subject>Epidermis - analysis</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Keratins - analysis</subject><subject>Keratoacanthoma - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - analysis</subject><subject>Protein Precursors - analysis</subject><subject>Sebaceous Glands - analysis</subject><subject>Skin Diseases - metabolism</subject><subject>Skin Neoplasms - analysis</subject><subject>Sweat Glands - analysis</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQQK0KRBfan4CUQ4XKIWA7iR33gipUKAKJQ9uz5Z1MtC6JDbazUit-PM7uaq9cPJbmzdcj5JTRC0aZuPxFmaKlEpx_bcW5pJSLkn0gC0aVLIVs5QFZ7JGP5DjGv5RSVVfyiBzxmqlK1gvyeo_BJG_AuLTyoymM64r4MpnRT7EAHIYCTADr5pzvi7TCIj5Z9624G8fJ-ZWNycMKRwtmKAafX_vfJOvdTFu39sMEwbpN36d5Vv4_B5_QuviJHPZmiPh5F0_In5sfv69_lg-Pt3fX3x9KqJsmlYLRSkJeXXLe0k5JNF0F2ApoBetlLZZSctEohVJUDeOcmmXfA7QIgEr11Qk52_bNg18mjEmPNs63GYf5TC2FZFmYyGCzBSH4GAP2-jnY0YR_mlE9W9cb63pWqluhN9Y1y3WnuwHTcsRuX7XTnPNfdnkTs6E-GAc27rG2aaSiPGNXWwyzjLXFoCNYdICdDQhJd96-s8gbG4ig-Q</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>Smoller, Bruce R.</creator><creator>Kwan, Theodore H.</creator><creator>Said, Jonathan W.</creator><creator>Banks-Schlegel, Susan</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860201</creationdate><title>Keratoacanthoma and squamous cell carcinoma of the skin: Immunohistochemical localization of involucrin and keratin proteins</title><author>Smoller, Bruce R. ; Kwan, Theodore H. ; Said, Jonathan W. ; Banks-Schlegel, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-61037c09472280d97ead3ce86c861f746b7726599e76351220abffcc8ecce99f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - analysis</topic><topic>Dermatology</topic><topic>Epidermis - analysis</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Keratins - analysis</topic><topic>Keratoacanthoma - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - analysis</topic><topic>Protein Precursors - analysis</topic><topic>Sebaceous Glands - analysis</topic><topic>Skin Diseases - metabolism</topic><topic>Skin Neoplasms - analysis</topic><topic>Sweat Glands - analysis</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smoller, Bruce R.</creatorcontrib><creatorcontrib>Kwan, Theodore H.</creatorcontrib><creatorcontrib>Said, Jonathan W.</creatorcontrib><creatorcontrib>Banks-Schlegel, Susan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smoller, Bruce R.</au><au>Kwan, Theodore H.</au><au>Said, Jonathan W.</au><au>Banks-Schlegel, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Keratoacanthoma and squamous cell carcinoma of the skin: Immunohistochemical localization of involucrin and keratin proteins</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>14</volume><issue>2</issue><spage>226</spage><epage>234</epage><pages>226-234</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Fifteen keratoacanthomas and fifteen squamous cell carcinomas of the skin were examined by immunoperoxidase methods for involucrin and both 45- and 63-kilodalton keratins. Keratoacanthomas showed a relatively homogeneous staining pattern for involucrin; all cells except basal cells stained with mild to moderate intensity. Squamous cell carcinomas disclosed a highly irregular involucrin staining pattern with marked variation in staining intensity from cell to cell. Staining patterns for keratin proteins did not appear to distinguish between keratoacanthomas and squamous cell carcinomas. The 45-kilodalton keratin pattern showed diffuse staining within both keratoacanthomas and squamous cell carcinomas, and the 63-kilodalton keratin pattern consisted of focal staining, mostly of dyskeratotic cells. These results suggest that involucrin may serve as a diagnostic aid in differentiating between squamous cell carcinomas and keratoacanthomas. In addition, other lesions in the differential diagnosis of keratoacanthoma and squamous cell carcinoma were also examined for involucrin.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2419374</pmid><doi>10.1016/S0190-9622(86)70026-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1986-02, Vol.14 (2), p.226-234 |
| issn | 0190-9622 1097-6787 |
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| subjects | Adult Aged Biological and medical sciences Carcinoma, Squamous Cell - analysis Dermatology Epidermis - analysis Histocytochemistry Humans Immunoenzyme Techniques Keratins - analysis Keratoacanthoma - metabolism Medical sciences Middle Aged Neoplasm Proteins - analysis Protein Precursors - analysis Sebaceous Glands - analysis Skin Diseases - metabolism Skin Neoplasms - analysis Sweat Glands - analysis Tumors of the skin and soft tissue. Premalignant lesions |
| title | Keratoacanthoma and squamous cell carcinoma of the skin: Immunohistochemical localization of involucrin and keratin proteins |
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