Doxapram Reversal of Respiratory Failure in a Patient Refusing Assisted Ventilation
A 75-year-old man with severe chronic obstructive pulmonary disease and epistaxis experienced progressive respiratory failure after receiving an injection of meperidine and hydroxyzine in preparation for nasal packing. The patient and his family refused endotracheal intubation; despite aggressive me...
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| Veröffentlicht in: | Annals of emergency medicine 1994-10, Vol.24 (4), p.751-754 |
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| container_title | Annals of emergency medicine |
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| creator | McNamara, Robert M Euerle, Brian D |
| description | A 75-year-old man with severe chronic obstructive pulmonary disease and epistaxis experienced progressive respiratory failure after receiving an injection of meperidine and hydroxyzine in preparation for nasal packing. The patient and his family refused endotracheal intubation; despite aggressive medical care, he continued to deteriorate toward an expected fatal outcome. An IV infusion of doxapram hydrochloride at 2 mg/min rapidly reversed his downhill course and hypercarbic coma. This case illustrates the potential usefulness of doxapram in the emergency setting. The mechanism of action, indications, dosing methods, and potential side effects of this agent are discussed. [McNamara RM, Euerle BD: Doxapram reversal of respiratory failure in a patient refusing assisted ventilation.
Ann Emerg Med October 1994;24:751-754.] |
| doi_str_mv | 10.1016/S0196-0644(94)70289-6 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Annals of emergency medicine, 1994-10, Vol.24 (4), p.751-754 |
| issn | 0196-0644 1097-6760 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Biological and medical sciences Combined Modality Therapy Doxapram - therapeutic use Epistaxis - complications Epistaxis - therapy Humans Male Medical sciences Pharmacology. Drug treatments Respiration, Artificial - psychology Respiratory Insufficiency - complications Respiratory Insufficiency - drug therapy Respiratory system Treatment Refusal |
| title | Doxapram Reversal of Respiratory Failure in a Patient Refusing Assisted Ventilation |
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