The morphological effects of the anti–tumor agents flavone acetic acid and 5,6–dimethyl xanthenone acetic acid on the colon 38 mouse tumor
Flavone acetic acid and 5,6-dimethyl xanthenone acetic acid have a broad spectrum of anti-tumor activity in mice, and act by stimulating immune cells and inhibiting tumor blood flow, resulting in hemorrhagic necrosis within 24 hrs. To study the evolution of hemorrhagic necrosis, subcutaneous Colon 3...
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| Veröffentlicht in: | Pathology 1994, Vol.26 (2), p.161-169 |
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| container_title | Pathology |
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| creator | Jonathan Zwi, L. Baguley, Bruce C. Gavin, John B. Wilson, William R. |
| description | Flavone acetic acid and 5,6-dimethyl xanthenone acetic acid have a broad spectrum of anti-tumor activity in mice, and act by stimulating immune cells and inhibiting tumor blood flow, resulting in hemorrhagic necrosis within 24 hrs. To study the evolution of hemorrhagic necrosis, subcutaneous Colon 38 tumors were examined by light and electron microscopy from 30 min to 24 hrs after treatment with these agents, and measurements of tumor energy metabolites made. The results show that both agents cause apoptosis beginning at 30 min, and that by 4 hrs necrosis supervenes, accompanied by rupture of tumor blood vessels. The absence of early endothelial cell damage or thrombosis suggests that vessel rupture, and consequent loss of blood flow and energy metabolite depletion, is caused by loss of extravascular mechanical support by the tumor parenchyma. |
| doi_str_mv | 10.1080/00313029400169411 |
| format | Article |
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To study the evolution of hemorrhagic necrosis, subcutaneous Colon 38 tumors were examined by light and electron microscopy from 30 min to 24 hrs after treatment with these agents, and measurements of tumor energy metabolites made. The results show that both agents cause apoptosis beginning at 30 min, and that by 4 hrs necrosis supervenes, accompanied by rupture of tumor blood vessels. The absence of early endothelial cell damage or thrombosis suggests that vessel rupture, and consequent loss of blood flow and energy metabolite depletion, is caused by loss of extravascular mechanical support by the tumor parenchyma.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.1080/00313029400169411</identifier><identifier>PMID: 8090588</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; adenosine triphosphate ; Adenosine Triphosphate - metabolism ; Animals ; Apoptosis - drug effects ; blood vessels ; Colonic Neoplasms - blood supply ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; flavone acetic acid ; Flavones ; Flavonoids - pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Microscopy, Electron ; Necrosis ; neoplasms ; Phosphocreatine - metabolism ; Xanthenes - pharmacology ; xanthenone acetic acid ; Xanthones</subject><ispartof>Pathology, 1994, Vol.26 (2), p.161-169</ispartof><rights>1994 Royal College of Pathologists of Australasia</rights><rights>1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-f3fee41846db41997c062d0d035ce6aff6d6971bd280e3640eb5b0bcca3862c3</citedby><cites>FETCH-LOGICAL-c315t-f3fee41846db41997c062d0d035ce6aff6d6971bd280e3640eb5b0bcca3862c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00313029400169411$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00313029400169411$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8090588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonathan Zwi, L.</creatorcontrib><creatorcontrib>Baguley, Bruce C.</creatorcontrib><creatorcontrib>Gavin, John B.</creatorcontrib><creatorcontrib>Wilson, William R.</creatorcontrib><title>The morphological effects of the anti–tumor agents flavone acetic acid and 5,6–dimethyl xanthenone acetic acid on the colon 38 mouse tumor</title><title>Pathology</title><addtitle>Pathology</addtitle><description>Flavone acetic acid and 5,6-dimethyl xanthenone acetic acid have a broad spectrum of anti-tumor activity in mice, and act by stimulating immune cells and inhibiting tumor blood flow, resulting in hemorrhagic necrosis within 24 hrs. To study the evolution of hemorrhagic necrosis, subcutaneous Colon 38 tumors were examined by light and electron microscopy from 30 min to 24 hrs after treatment with these agents, and measurements of tumor energy metabolites made. The results show that both agents cause apoptosis beginning at 30 min, and that by 4 hrs necrosis supervenes, accompanied by rupture of tumor blood vessels. The absence of early endothelial cell damage or thrombosis suggests that vessel rupture, and consequent loss of blood flow and energy metabolite depletion, is caused by loss of extravascular mechanical support by the tumor parenchyma.</description><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>adenosine triphosphate</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>blood vessels</subject><subject>Colonic Neoplasms - blood supply</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>flavone acetic acid</subject><subject>Flavones</subject><subject>Flavonoids - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Microscopy, Electron</subject><subject>Necrosis</subject><subject>neoplasms</subject><subject>Phosphocreatine - metabolism</subject><subject>Xanthenes - pharmacology</subject><subject>xanthenone acetic acid</subject><subject>Xanthones</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9q3DAQxkVpSDdpH6CHgk89xc1oZWtleiqh_yDQy96NLI1iBVvaSnJobnmCXvKGeZJOsksPLQQEc_h-3zejGcbecvjAQcE5gOAC1l0DwGXXcP6CrXgj21p0gr9kq0e9JqB9xU5yvgaARil1zI4VdNAqtWK_tyNWc0y7MU7xyhs9VegcmpKr6KpCog7FP9zdl4WoSl9hIMlN-iYG0gwWb6h4S5yt2jNJqPUzlvF2qn6Rd8TwLxnDU7ChjqESitovGaunBq_ZkdNTxjeHesq2Xz5vL77Vlz--fr_4dFkbwdtSO-EQG64aaYeGd93GgFxbsCBag1I7J63sNnywawUoZAM4tAMMxmih5NqIU_Z-H7tL8eeCufSzzwanSQekYfqN3PCWHoF8D5oUc07o-l3ys063PYf-8QT9fycgz7tD-DLMaP86Djsn_eNe98HFNOsR9VRGoxP213FJgf79bPrBjbSeG4-pz8ZjMGh9orP1Nvpn3H8Ao0mpQQ</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Jonathan Zwi, L.</creator><creator>Baguley, Bruce C.</creator><creator>Gavin, John B.</creator><creator>Wilson, William R.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>The morphological effects of the anti–tumor agents flavone acetic acid and 5,6–dimethyl xanthenone acetic acid on the colon 38 mouse tumor</title><author>Jonathan Zwi, L. ; Baguley, Bruce C. ; Gavin, John B. ; Wilson, William R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-f3fee41846db41997c062d0d035ce6aff6d6971bd280e3640eb5b0bcca3862c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>adenosine triphosphate</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>blood vessels</topic><topic>Colonic Neoplasms - blood supply</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>flavone acetic acid</topic><topic>Flavones</topic><topic>Flavonoids - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Microscopy, Electron</topic><topic>Necrosis</topic><topic>neoplasms</topic><topic>Phosphocreatine - metabolism</topic><topic>Xanthenes - pharmacology</topic><topic>xanthenone acetic acid</topic><topic>Xanthones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonathan Zwi, L.</creatorcontrib><creatorcontrib>Baguley, Bruce C.</creatorcontrib><creatorcontrib>Gavin, John B.</creatorcontrib><creatorcontrib>Wilson, William R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonathan Zwi, L.</au><au>Baguley, Bruce C.</au><au>Gavin, John B.</au><au>Wilson, William R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The morphological effects of the anti–tumor agents flavone acetic acid and 5,6–dimethyl xanthenone acetic acid on the colon 38 mouse tumor</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>1994</date><risdate>1994</risdate><volume>26</volume><issue>2</issue><spage>161</spage><epage>169</epage><pages>161-169</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>Flavone acetic acid and 5,6-dimethyl xanthenone acetic acid have a broad spectrum of anti-tumor activity in mice, and act by stimulating immune cells and inhibiting tumor blood flow, resulting in hemorrhagic necrosis within 24 hrs. To study the evolution of hemorrhagic necrosis, subcutaneous Colon 38 tumors were examined by light and electron microscopy from 30 min to 24 hrs after treatment with these agents, and measurements of tumor energy metabolites made. The results show that both agents cause apoptosis beginning at 30 min, and that by 4 hrs necrosis supervenes, accompanied by rupture of tumor blood vessels. The absence of early endothelial cell damage or thrombosis suggests that vessel rupture, and consequent loss of blood flow and energy metabolite depletion, is caused by loss of extravascular mechanical support by the tumor parenchyma.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>8090588</pmid><doi>10.1080/00313029400169411</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 1994, Vol.26 (2), p.161-169 |
| issn | 0031-3025 1465-3931 |
| language | eng |
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| source | Taylor & Francis; MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adenocarcinoma - pathology adenosine triphosphate Adenosine Triphosphate - metabolism Animals Apoptosis - drug effects blood vessels Colonic Neoplasms - blood supply Colonic Neoplasms - metabolism Colonic Neoplasms - pathology flavone acetic acid Flavones Flavonoids - pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Microscopy, Electron Necrosis neoplasms Phosphocreatine - metabolism Xanthenes - pharmacology xanthenone acetic acid Xanthones |
| title | The morphological effects of the anti–tumor agents flavone acetic acid and 5,6–dimethyl xanthenone acetic acid on the colon 38 mouse tumor |
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