Enhanced production of interleukin-1, tumor necrosis factor-alpha, and fibronectin by rat lung phagocytes following inhalation of a pulmonary irritant

Interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), and fibronectin are macrophage-derived mediators thought to be important in the pathogenesis of lung injury, inflammation, and fibrosis. In the present studies, we examined the effects of acute exposure of rats to the pulmonary irritant,...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1994-09, Vol.11 (3), p.279-286
Hauptverfasser:	Pendino, KJ, Shuler, RL, Laskin, JD, Laskin, DL
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Female Fibronectins - biosynthesis Gas, fumes Interferon-gamma - pharmacology Interleukin-1 - biosynthesis Lipopolysaccharides - pharmacology Lung - cytology Lung - immunology Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Medical sciences Ozone - administration & dosage Ozone - pharmacology Phagocytes - drug effects Phagocytes - immunology Rats Rats, Sprague-Dawley Specific Pathogen-Free Organisms Toxicology Transforming Growth Factor beta - pharmacology Tumor Necrosis Factor-alpha - biosynthesis
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