Optimization of monoclonal antibody delivery via the lymphatics: the dose dependence

After interstitial injection in mice, antibody molecules enter local lymphatic vessels, flow with the lymph to regional lymph nodes, and bind to target antigens there. Compared with i.v. administration, delivery via the lymphatics provides a more efficient means for localizing antibody in lymph node...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1986-04, Vol.46 (4), p.1830-1834
Hauptverfasser:	STELLER, M. A, PARKER, R. J, COVELL, D. G, HOLTON, O. D. III, KEENAN, A. M, SIEBER, S. M, WEINSTEIN, J. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - physiology Biological and medical sciences Dose-Response Relationship, Drug H-2 Antigens - immunology Immunological methods for diagnosis and exploration Immunopathology Iodine Radioisotopes Lymph Nodes - metabolism Lymphatic Metastasis Lymphatic System - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Weight Other methods Temperature
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