Molecular requirement for interleukin 1 induction by lipopolysaccharide‐stimulated human monocytes: Involvement of the heptosyl‐2‐keto 3‐deoxyoctulosonate region

Experiments were undertaken to localize in the lipopolysaccharide (LPS) the minimal structural determinants sufficient to initiate the signal leading to interleukin 1 (IL 1) secretion by human monocytes. Our results clearly demonstrated that this signal is triggered by structures present in the so‐c...

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Veröffentlicht in:	European journal of immunology 1986, Vol.16 (1), p.87-91
Hauptverfasser:	Lebbar, Souad, Cavaillon, Jean‐Marc, Caroff, Martine, Ledur, Annick, Brade, Helmut, Sarfati, Robert, Haeffner‐Cavaillon, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Carbohydrate Sequence Disaccharides - immunology Endotoxins - immunology Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Gram-Negative Bacteria - immunology Humans Immunobiology Interleukin-1 - biosynthesis Lipopolysaccharides - immunology Lymphokines, interleukins ( function, expression) Monocytes - immunology Regulatory factors and their cellular receptors Salmonella - immunology Structure-Activity Relationship Sugar Acids - immunology
Online-Zugang:	Volltext
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