An Interleukin-4-Induced Transcription Factor: IL-4 Stat

Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-09, Vol.265 (5179), p.1701-1706
Hauptverfasser:	Hou, Jinzhao, Schindler, Ulrike, Henzel, William J., Ho, Tze Chun, Brasseur, Mike, McKnight, Steven L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids B lymphocytes Base Sequence Biochemistry Biological and medical sciences Cell Line Cell physiology cloning Cloning, Molecular Cross-Linking Reagents Crosslinking Deoxyribonucleic acid Dimerization Dimers DNA DNA - metabolism DNA binding proteins DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology gene expression Genes Humans IL-4 Stat protein Immune response Immune response regulation Immunity (Disease) induction Interleukin-4 Interleukin-4 - pharmacology Interleukin-4 Receptor alpha Subunit man Messenger RNA Models, Biological Molecular and cellular biology Molecular Sequence Data Monocytes - metabolism Phosphopeptides - metabolism Phosphopeptides - pharmacology Phosphorylation Polymers prediction Proteins Receptors Receptors, Cell Surface Receptors, Interleukin-4 Receptors, Mitogen - metabolism Regulation Responses to growth factors, tumor promotors, other factors Somatic cells STAT6 Transcription Factor Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - isolation & purification Trans-Activators - metabolism transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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