EFFECTS OF EXTRADURAL BUPIVACAINE ON THE HAEMOSTATIC SYSTEM
Twenty consecutive patients undergoing elective transurethral resection of the prostate were allocated randomly to one of two groups. Group I (n = 10) received lumbar extradural analgesia with 0.5% bupivacaine. Group I (n = 10) received general anaesthesia with spontaneous respiration, using 60% nit...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-03, Vol.58 (3), p.301-305 |
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| container_title | British journal of anaesthesia : BJA |
| container_volume | 58 |
| creator | HENNY, C.P. ODOOM, J.A. CATE, H. TEN CATE, J.W. TEN OOSTERHOFF, R.J.F. DABHOIWALA, N.F. SIH, I.L. |
| description | Twenty consecutive patients undergoing elective transurethral resection of the prostate were allocated randomly to one of two groups. Group I (n = 10) received lumbar extradural analgesia with 0.5% bupivacaine. Group I (n = 10) received general anaesthesia with spontaneous respiration, using 60% nitrous oxide and 1–2% halothane in oxygen. There was a significant inhibitory effect on platelet aggregation in the extradural group. No such effect was observed in the general anaesthesia group. Measured indices of coagulation and fibrinolysis showed no abnormalities compared with control in either group except for a significant decrease in alpha2-antiplasmin during surgery in group II. These results suggest that the possible thromboprophylatic effect of extradural analgesia with bupivacaine may result from an inhibitory effect on platelet aggregation which is in addition to the increase in lower limb blood flow. |
| doi_str_mv | 10.1093/bja/58.3.301 |
| format | Article |
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These results suggest that the possible thromboprophylatic effect of extradural analgesia with bupivacaine may result from an inhibitory effect on platelet aggregation which is in addition to the increase in lower limb blood flow.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/58.3.301</identifier><identifier>PMID: 3947491</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia, Epidural ; Anesthesia, General ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Bupivacaine - pharmacology ; Depression, Chemical ; Hemostasis - drug effects ; Humans ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. 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Measured indices of coagulation and fibrinolysis showed no abnormalities compared with control in either group except for a significant decrease in alpha2-antiplasmin during surgery in group II. These results suggest that the possible thromboprophylatic effect of extradural analgesia with bupivacaine may result from an inhibitory effect on platelet aggregation which is in addition to the increase in lower limb blood flow.</description><subject>Anesthesia, Epidural</subject><subject>Anesthesia, General</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine - pharmacology</subject><subject>Depression, Chemical</subject><subject>Hemostasis - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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TEN ; OOSTERHOFF, R.J.F. ; DABHOIWALA, N.F. ; SIH, I.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4481-f00df6ed3f51547530c596c55e34a8d3e4a786fbd0da869426f30fa11a6343663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia, Epidural</topic><topic>Anesthesia, General</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine - pharmacology</topic><topic>Depression, Chemical</topic><topic>Hemostasis - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. 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No such effect was observed in the general anaesthesia group. Measured indices of coagulation and fibrinolysis showed no abnormalities compared with control in either group except for a significant decrease in alpha2-antiplasmin during surgery in group II. These results suggest that the possible thromboprophylatic effect of extradural analgesia with bupivacaine may result from an inhibitory effect on platelet aggregation which is in addition to the increase in lower limb blood flow.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3947491</pmid><doi>10.1093/bja/58.3.301</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Anesthesia, Epidural Anesthesia, General Anesthetics. Neuromuscular blocking agents Biological and medical sciences Bupivacaine - pharmacology Depression, Chemical Hemostasis - drug effects Humans Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Platelet Aggregation - drug effects Prostatectomy |
| title | EFFECTS OF EXTRADURAL BUPIVACAINE ON THE HAEMOSTATIC SYSTEM |
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