Treatment of Hairy Cell Leukemia With Recombinant Alpha Interferon: II. In Vivo Down-Regulation of Alpha Interferon Receptors on Tumor Cells

Interferons (IFNs) initiate their effects by interacting with specific high-affinity cell surface receptors, but little is known about the physiology of IFN receptor interaction in vivo. Treatment of patients suffering from hairy cell leukemia (HCL) with human recombinant alpha IFN results in signif...

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