The effect of food on oral melphalan absorption

Fifteen patients receiving oral melphalan (4.2-5.3 mg/m2) for a variety of neoplastic disorders were studied. Ten patients received the drug on separate occasions, with and without a standardized breakfast. Eight of these patients also received an IV bolus dose (5 mg/m2) to determine bioavailability...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1986-03, Vol.16 (2), p.194-197
Hauptverfasser:	REECE, P. A, KOTASEK, D, MORRIS, R. G, DALE, B. M, SAGE, R. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Aged Antineoplastic agents Biological and medical sciences Biological Availability Chemotherapy Chromatography, High Pressure Liquid Fasting Female Food Humans Injections, Intravenous Kinetics Male Medical sciences Melphalan - administration & dosage Melphalan - blood Melphalan - metabolism Melphalan - therapeutic use Middle Aged Neoplasms - drug therapy Pharmacology. Drug treatments
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