Three-Year Incidence of AIDS in Five Cohorts of HTLV-III-Infected Risk Group Members
The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1986-02, Vol.231 (4741), p.992-995 |
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| creator | Goedert, James J. Biggar, Robert J. Weiss, Stanley H. Eyster, M. Elaine Melbye, Mads Wilson, Susan Ginzburg, Harold M. Grossman, Ronald J. DiGioia, Richard A. Sanchez, William C. Giron, José A. Ebbesen, Peter Gallo, Robert C. Blattner, William A. |
| description | The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral drug users, and hemophiliacs. A total of 276 (38.1 percent) of the subjects were either HTLV-III seropositive at enrollment or developed HTLV-III antibodies subsequently. AIDS had developed in 28 (10.1 percent) of the seropositive subjects before August 1985. By actuarial survival calculations, the 3-year incidence of AIDS among all HTLV-III seropositive subjects was 34.2 percent in the cohort of homosexual men in Manhattan, New York, and 14.9 percent (range 8.0 to 17.2 percent) in the four other cohorts. Out of 117 subjects followed for a mean of 31 months after documented seroconversion, five (all hemophiliacs) developed AIDS 28 to 62 months after the estimated date of seroconversion, supporting the hypothesis that there is a long latency between acquisition of viral infection and the development of clinical AIDS. This long latency could account for the significantly higher AIDS incidence in the New York cohort compared with other cohorts if the virus entered the New York homosexual population before it entered the populations from which the other cohorts were drawn. However, risk of AIDS development in different populations may also depend on the presence of as yet unidentified cofactors. |
| doi_str_mv | 10.1126/science.3003917 |
| format | Article |
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Elaine ; Melbye, Mads ; Wilson, Susan ; Ginzburg, Harold M. ; Grossman, Ronald J. ; DiGioia, Richard A. ; Sanchez, William C. ; Giron, José A. ; Ebbesen, Peter ; Gallo, Robert C. ; Blattner, William A.</creator><creatorcontrib>Goedert, James J. ; Biggar, Robert J. ; Weiss, Stanley H. ; Eyster, M. Elaine ; Melbye, Mads ; Wilson, Susan ; Ginzburg, Harold M. ; Grossman, Ronald J. ; DiGioia, Richard A. ; Sanchez, William C. ; Giron, José A. ; Ebbesen, Peter ; Gallo, Robert C. ; Blattner, William A.</creatorcontrib><description>The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral drug users, and hemophiliacs. A total of 276 (38.1 percent) of the subjects were either HTLV-III seropositive at enrollment or developed HTLV-III antibodies subsequently. AIDS had developed in 28 (10.1 percent) of the seropositive subjects before August 1985. By actuarial survival calculations, the 3-year incidence of AIDS among all HTLV-III seropositive subjects was 34.2 percent in the cohort of homosexual men in Manhattan, New York, and 14.9 percent (range 8.0 to 17.2 percent) in the four other cohorts. Out of 117 subjects followed for a mean of 31 months after documented seroconversion, five (all hemophiliacs) developed AIDS 28 to 62 months after the estimated date of seroconversion, supporting the hypothesis that there is a long latency between acquisition of viral infection and the development of clinical AIDS. This long latency could account for the significantly higher AIDS incidence in the New York cohort compared with other cohorts if the virus entered the New York homosexual population before it entered the populations from which the other cohorts were drawn. However, risk of AIDS development in different populations may also depend on the presence of as yet unidentified cofactors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3003917</identifier><identifier>PMID: 3003917</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - microbiology ; Acquired Immunodeficiency Syndrome - physiopathology ; Acquired Immunodeficiency Syndrome - transmission ; AIDS ; AIDS/HIV ; Antibodies ; Antibodies, Viral - analysis ; Biological and medical sciences ; Deltaretrovirus - metabolism ; Demographics ; Denmark ; Hemophilia A - microbiology ; HIV ; HIV infections ; Homosexuality ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Kaposi sarcoma ; Male ; Male homosexuality ; Medical research ; Medical sciences ; Men ; New York City ; Risk ; Sarcoma, Kaposi - microbiology ; Time Factors ; United States ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1986-02, Vol.231 (4741), p.992-995</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1987 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science Feb 28, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-bc42309981cf20859b88dbba5c5969f0752b8a3a6fe2a768ffbfb9318c9a58963</citedby><cites>FETCH-LOGICAL-c407t-bc42309981cf20859b88dbba5c5969f0752b8a3a6fe2a768ffbfb9318c9a58963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1696964$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1696964$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7887113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3003917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goedert, James J.</creatorcontrib><creatorcontrib>Biggar, Robert J.</creatorcontrib><creatorcontrib>Weiss, Stanley H.</creatorcontrib><creatorcontrib>Eyster, M. Elaine</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Wilson, Susan</creatorcontrib><creatorcontrib>Ginzburg, Harold M.</creatorcontrib><creatorcontrib>Grossman, Ronald J.</creatorcontrib><creatorcontrib>DiGioia, Richard A.</creatorcontrib><creatorcontrib>Sanchez, William C.</creatorcontrib><creatorcontrib>Giron, José A.</creatorcontrib><creatorcontrib>Ebbesen, Peter</creatorcontrib><creatorcontrib>Gallo, Robert C.</creatorcontrib><creatorcontrib>Blattner, William A.</creatorcontrib><title>Three-Year Incidence of AIDS in Five Cohorts of HTLV-III-Infected Risk Group Members</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral drug users, and hemophiliacs. A total of 276 (38.1 percent) of the subjects were either HTLV-III seropositive at enrollment or developed HTLV-III antibodies subsequently. AIDS had developed in 28 (10.1 percent) of the seropositive subjects before August 1985. By actuarial survival calculations, the 3-year incidence of AIDS among all HTLV-III seropositive subjects was 34.2 percent in the cohort of homosexual men in Manhattan, New York, and 14.9 percent (range 8.0 to 17.2 percent) in the four other cohorts. Out of 117 subjects followed for a mean of 31 months after documented seroconversion, five (all hemophiliacs) developed AIDS 28 to 62 months after the estimated date of seroconversion, supporting the hypothesis that there is a long latency between acquisition of viral infection and the development of clinical AIDS. This long latency could account for the significantly higher AIDS incidence in the New York cohort compared with other cohorts if the virus entered the New York homosexual population before it entered the populations from which the other cohorts were drawn. However, risk of AIDS development in different populations may also depend on the presence of as yet unidentified cofactors.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - microbiology</subject><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Acquired Immunodeficiency Syndrome - transmission</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Deltaretrovirus - metabolism</subject><subject>Demographics</subject><subject>Denmark</subject><subject>Hemophilia A - microbiology</subject><subject>HIV</subject><subject>HIV infections</subject><subject>Homosexuality</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Kaposi sarcoma</subject><subject>Male</subject><subject>Male homosexuality</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Men</subject><subject>New York City</subject><subject>Risk</subject><subject>Sarcoma, Kaposi - microbiology</subject><subject>Time Factors</subject><subject>United States</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctrGzEQxkVpSJyk515aECXktokeu3ocg5vHgkMgdQs9LZI8IuvYK1faLeS_j4yXBHLxaWC-n74ZzYfQV0ouKGXiMrkWOgcXnBCuqfyEJpToqtCM8M9okpuiUERWR-g4pSUhWdP8EB2O-ATN508RoPgLJuK6c-1i64aDx1f1z1-47fBN-x_wNDyF2Kdt_24--1PUdV3UnQfXwwI_tukZ38YwbPA9rC3EdIoOvFkl-DLWE_T75no-vStmD7f19GpWuJLIvrCuZJxorajzjKhKW6UW1prKVVpon9dmVhluhAdmpFDeW281p8ppUykt-Ak63_luYvg3QOqbdZscrFamgzCkRgpJOM8_3gdywVQ-yH5HRqmsZFnuBWlZloIxmsEfH8BlGGKXz5LNeMWE1Fvocge5GFKK4JtNbNcmvjSUNNucmzHnZgwuv_g-2g52DYs3_l0_G3WTnFn5aHK46Q2TSklKeca-7bBl6kN8nypyAKLkr7n-tss</recordid><startdate>19860228</startdate><enddate>19860228</enddate><creator>Goedert, James J.</creator><creator>Biggar, Robert J.</creator><creator>Weiss, Stanley H.</creator><creator>Eyster, M. 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Elaine ; Melbye, Mads ; Wilson, Susan ; Ginzburg, Harold M. ; Grossman, Ronald J. ; DiGioia, Richard A. ; Sanchez, William C. ; Giron, José A. ; Ebbesen, Peter ; Gallo, Robert C. ; Blattner, William A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-bc42309981cf20859b88dbba5c5969f0752b8a3a6fe2a768ffbfb9318c9a58963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - microbiology</topic><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Acquired Immunodeficiency Syndrome - transmission</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Deltaretrovirus - metabolism</topic><topic>Demographics</topic><topic>Denmark</topic><topic>Hemophilia A - microbiology</topic><topic>HIV</topic><topic>HIV infections</topic><topic>Homosexuality</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. 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Elaine</au><au>Melbye, Mads</au><au>Wilson, Susan</au><au>Ginzburg, Harold M.</au><au>Grossman, Ronald J.</au><au>DiGioia, Richard A.</au><au>Sanchez, William C.</au><au>Giron, José A.</au><au>Ebbesen, Peter</au><au>Gallo, Robert C.</au><au>Blattner, William A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-Year Incidence of AIDS in Five Cohorts of HTLV-III-Infected Risk Group Members</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1986-02-28</date><risdate>1986</risdate><volume>231</volume><issue>4741</issue><spage>992</spage><epage>995</epage><pages>992-995</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The incidence of the acquired immune deficiency syndrome (AIDS) among persons infected with human T-lymphotropic virus type III (HTLV-III) was evaluated prospectively among 725 persons who were at high risk of AIDS and had enrolled before October 1982 in cohort studies of homosexual men, parenteral drug users, and hemophiliacs. A total of 276 (38.1 percent) of the subjects were either HTLV-III seropositive at enrollment or developed HTLV-III antibodies subsequently. AIDS had developed in 28 (10.1 percent) of the seropositive subjects before August 1985. By actuarial survival calculations, the 3-year incidence of AIDS among all HTLV-III seropositive subjects was 34.2 percent in the cohort of homosexual men in Manhattan, New York, and 14.9 percent (range 8.0 to 17.2 percent) in the four other cohorts. Out of 117 subjects followed for a mean of 31 months after documented seroconversion, five (all hemophiliacs) developed AIDS 28 to 62 months after the estimated date of seroconversion, supporting the hypothesis that there is a long latency between acquisition of viral infection and the development of clinical AIDS. This long latency could account for the significantly higher AIDS incidence in the New York cohort compared with other cohorts if the virus entered the New York homosexual population before it entered the populations from which the other cohorts were drawn. However, risk of AIDS development in different populations may also depend on the presence of as yet unidentified cofactors.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3003917</pmid><doi>10.1126/science.3003917</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1986-02, Vol.231 (4741), p.992-995 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - microbiology Acquired Immunodeficiency Syndrome - physiopathology Acquired Immunodeficiency Syndrome - transmission AIDS AIDS/HIV Antibodies Antibodies, Viral - analysis Biological and medical sciences Deltaretrovirus - metabolism Demographics Denmark Hemophilia A - microbiology HIV HIV infections Homosexuality Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Kaposi sarcoma Male Male homosexuality Medical research Medical sciences Men New York City Risk Sarcoma, Kaposi - microbiology Time Factors United States Viruses |
| title | Three-Year Incidence of AIDS in Five Cohorts of HTLV-III-Infected Risk Group Members |
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