Time Dependency in the Regenerative Response to Injury of the Rat Corneal Epithelium
In the present study a central corneal epithelial defect (diameter 3.5 mm) was made in both eyes at 12:00 h in one group of rats and at 24:00 h in another group to see if the regenerative proliferation is influenced by circadian rhythms. The labeling index and the mitotic rate were registered at 4-h...
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| Veröffentlicht in: | Chronobiology international 1994, Vol.11 (3), p.173-179 |
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| creator | Sandvig, Kjell U. Haaskjold, Erling Refsum, Sigvald B. |
| description | In the present study a central corneal epithelial defect (diameter 3.5 mm) was made in both eyes at 12:00 h in one group of rats and at 24:00 h in another group to see if the regenerative proliferation is influenced by circadian rhythms. The labeling index and the mitotic rate were registered at 4-h intervals in the perilimbal conjunctiva, the limbal area, and different parts of the cornea from the following morning until noon the day after that. The most pronounced regenerative proliferation was seen in the midperipheral and peripheral cornea. The regenerative response occurred in both groups 24-28 h after the injury, but was highly influenced by the normal circadian rhythms, especially with regard to the mitotic rate. The results support the theory that even regeneration is influenced by a circadian proliferative factor. |
| doi_str_mv | 10.3109/07420529409057237 |
| format | Article |
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The labeling index and the mitotic rate were registered at 4-h intervals in the perilimbal conjunctiva, the limbal area, and different parts of the cornea from the following morning until noon the day after that. The most pronounced regenerative proliferation was seen in the midperipheral and peripheral cornea. The regenerative response occurred in both groups 24-28 h after the injury, but was highly influenced by the normal circadian rhythms, especially with regard to the mitotic rate. 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| fulltext | fulltext |
| identifier | ISSN: 0742-0528 |
| ispartof | Chronobiology international, 1994, Vol.11 (3), p.173-179 |
| issn | 0742-0528 1525-6073 |
| language | eng |
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| source | Taylor & Francis; MEDLINE |
| subjects | Animals Circadian Rhythm Conjunctiva - physiology Conjunctiva - physiopathology Cornea - physiology Cornea - physiopathology Corneal Injuries Darkness Epithelium - physiology Female Light Rats Rats, Wistar Regeneration - physiology Wound Healing - physiology |
| title | Time Dependency in the Regenerative Response to Injury of the Rat Corneal Epithelium |
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